4703-22-4

Basic information

• Product Name: 1-[(4-methylphenyl)sulfonyl]piperidine
• Synonyms: 1-[(4-methylphenyl)sulfonyl]piperidine;1-(p-Tolylsulfonyl)piperidine;4-Methylphenylpiperidino sulfone;Piperidino(4-methylphenyl) sulfone
• CAS NO: 4703-22-4
• Molecular Formula: C₁₂H₁₇NO₂S
• Molecular Weight: 239.33
• Mol File: 4703-22-4.mol
• Article Data: 101

Chemical Properties

• Boiling Point: 368.2°C at 760 mmHg
• Flash Point: 176.5°C
• Appearance: /
• Density: 1.19g/cm³
• Vapor Pressure: 1.29E-05mmHg at 25°C
• Refractive Index: 1.561
• CAS DataBase Reference: 1-[(4-methylphenyl)sulfonyl]piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[(4-methylphenyl)sulfonyl]piperidine(4703-22-4)
• EPA Substance Registry System: 1-[(4-methylphenyl)sulfonyl]piperidine(4703-22-4)

Safety Data

• Hazardous Substances Data: 4703-22-4(Hazardous Substances Data)

Usage

Chemical structure

Contains a piperidine ring with a sulfonyl group attached to a 4-methylphenyl moiety.

Usage

Commonly used as a precursor in the synthesis of various pharmaceuticals and agrochemicals.

Polar properties

The sulfonyl group imparts polar properties to the compound.

Acidic properties

The sulfonyl group also imparts acidic properties to the compound.

Basic properties

The presence of the piperidine ring confers basic properties to the compound.

Versatility

Useful in organic synthesis reactions and as a building block in the production of drugs and other bioactive compounds.

Applications

Finds applications in the pharmaceutical, chemical, and agricultural industries.

InChI:InChI=1/C12H17NO2S/c1-11-5-7-12(8-6-11)16(14,15)13-9-3-2-4-10-13/h5-8H,2-4,9-10H2,1H3

Upstream product

• 42331-06-6 N-tosyl-5-chloropentylamine 
• 110-89-4 piperidine 
• 1153-45-3 4-nitrophenyl 4-methylbenzenesulfonate 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 29981-92-8 1-tosyl-3-methyl-imidazolium chloride 
• 92163-82-1 3-(p-tolylsulfonyl)-2(3H)-benzothiazolone 
• 2156-71-0 N-chloropiperidine 
• 536-57-2 p-toluene sulfinic acid 
• 111-24-0 1,5-dibromo-pentane 
• 29281-83-2 4-methylbenzensulphonamide potassium salt 
• 16780-44-2 N-(5-hydroxy-pentyl)-4-methyl-benzenesulfonamide 
• 143590-76-5 4-Methyl-N-(5-phenylselanyl-pentyl)-benzenesulfonamide 
• 100649-37-4 N-tosyl-5-bromopentylamine 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 1201516-76-8 2-(octan-2-yl)-1-tosylpiperidine 
• 433-06-7 2,2,2-Trifluoroethyl p-toluenesulfonate 
• 63587-57-5 2-methyl-1-(toluene-4-sulfonyl)-piperidine 
• 6091-44-7 piperidine hydrochloride 
• 91411-09-5 1-<(4-Methylphenyl)sulfonyl>-2,6-dimethoxypiperidine 
• 134415-28-4 1-<(4-Methylphenyl)sulfonyl>-2-methoxypiperidine 
• 1950-78-3 p-toluenesulfonyl iodide 
• 3333-08-2 N,N-dimethylpiperidinium iodide 

Relevant articles and documents

Direct Hydrodecarboxylation of Aliphatic Carboxylic Acids: Metal- and Light-Free

A mild and inexpensive method for direct hydrodecarboxylation of aliphatic carboxylic acids has been developed. The reaction does not require metals, light, or catalysts, rendering the protocol operationally simple, easy to scale, and more sustainable. Crucially, no additional H atom source is required in most cases, while a broad substrate scope and functional group tolerance are observed.

S(vi) in three-component sulfonamide synthesis: Use of sulfuric chloride as a linchpin in palladium-catalyzed Suzuki-Miyaura coupling

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