47030-01-3

Upstream product

• 71-23-8 propan-1-ol 
• 7475-56-1 chloro(diphenyl)acetic acid 
• 94686-44-9 diphenyl-propoxy-acetic acid propyl ester 
• 54556-98-8 propiverine hydrochloride 
• 56290-12-1 chloro-diphenyl-acetic acid propyl ester 
• 2766-01-0 α.α-Diphenyl-α-propargyloxyessigsaeure 
• 88857-84-5 N-(chloro-diphenyl-acetyl)-N'-methyl-urea 

Downstream Products

• 102752-75-0 diphenyl-propoxy-acetic acid-(2-diethylamino-ethyl ester) 
• 128887-47-8 Diphenyl-propoxy-acetic acid 3-azepan-1-yl-propyl ester 
• 87415-87-0 Diphenyl-propoxy-acetic acid 3-diethylamino-2-hydroxy-propyl ester; hydrochloride 

Relevant academic research and scientific papers

Raney nickel-catalyzed hydrogenation of unsaturated carboxylic acids with sodium borohydride in water

A mild, selective, and green method for the reduction of unsaturated carboxylic acids with sodium borohydride-Raney nickel (W6) system in water is reported. This method is practical and safe and avoids use of organic solvents. Taylor & Francis Group, LLC.

Biomimetic investigations of propiverinhydrochloride and 1-methyl-4-piperidyl benzilate

The reaction of propiverinhydrochloride (1) and 1-methyl-4-piperidyl benzilate (2) with the biomimetic system manganese(III)-5,10,15,20-tetrakis(pentafluorophenyl)-β-tetrasulfonat oporphyrin chloride (MnTPFPS4PCl)/imidazole/hydrogen peroxide in aqueous solution at pH 7-8 affords unchanged 1 and 2 and numerous metabolites, which are products of fission of the ester bond, of O-dealkylation, decarboxylation, N-demethylation, and oxidation of the tertiary amine function. In contrast to the nonaqueous system with the catalyst manganese(III)-5,10,15,20-tetrakis(pentafluorophenyl)porphyrin chloride (MnTPFPPCl) aromatic hydroxylation is not observed. This result shows conformity with the studies of metabolism in men.

Biomimetic oxidation of propiverinhydrochloride and 1-methyl-4-piperidyl benzilate

The reaction of propiverinhydrochloride (1) and 1-methyl-4-piperidyl benzilate (2) with the biomimetic system manganese(III)-5,10,15,20-tetrakis(pentafluorophenyl)porphyrin chloride (MnTPFPPCl)/pyridine/hydrogen peroxide affords unchanged 1 and 2 and 15 potential metabolites, which were isolated and identified. These compounds are products of cleavage of the ester bond, of O-dealkylation, aromatic oxidation, respectively of decarboxylation, demethylation, and N-oxidation. Products were identified by TLC, UV, and MS in comparison with authentic samples. Thereby we found a nearly conformity with rat metabolism.