4704-14-7Relevant articles and documents
Brasilicardins B-D, new tricyclic terpernoids from actinomycete Nocardia brasiliensis
Komatsu, Kazusei,Tsuda, Masashi,Shiro, Motoo,Tanaka, Yasushi,Mikami, Yuzuru,Kobayashi, Jun'Ichi
, p. 5545 - 5551 (2007/10/03)
Three new tricyclic terpenoids, brasilicardins B-D (2-4), were isolated together with brasilicardin A (1), a potent immunosuppressive compound, from the cultured broth of a pathogenic actinomycete Nocardia brasiliensis IFM0406, and the structures and stereochemistry were determined by spectroscopic data and a single crystal X-ray diffraction analysis. The immunosuppressive and cytotoxic activities of 2-4 were examined in the comparison with 1.