95015-29-5

Upstream product

• 100-39-0 benzyl bromide 
• 211237-60-4 methyl 2-azido-4-O-benzyl-2-deoxy-α-D-glucopyranoside 
• 251324-44-4 methyl 2-azido-2-deoxy-α-D-glucopyranoside 
• 7512-17-6 N-Acetyl-D-glucosamine 
• 4704-14-7 methyl 2-amino-2-deoxy-α-D-glucopyranoside 
• 14131-68-1 N-acetyl-D-glucosamine 
• 20672-67-7 methyl 3,4,6-tri-O-benzyl-α-D-mannopyranoside 
• 55682-47-8 1,6-anhydro-2-azido-4-O-benzyl-2-deoxy-β-D-glucopyranose 
• 110911-35-8 methyl-3,4,6-tri-O-benzyl-2-O-(N-imidazolylsulfonyl)-α-D-mannopyranoside 

Downstream Products

• 242142-78-5 Methyl 2-amino-3,4,6-tri-O-benzyl-2-deoxy-α-D-glucopyranoside 
• 211237-82-0 methyl 3,4,6-tri-O-benzyl-2-deoxy-2-isothiocyanato-α-D-glucopyranoside 
• 211238-37-8 1-((2S,3R,4R,5S,6R)-4,5-Bis-benzyloxy-6-benzyloxymethyl-2-methoxy-tetrahydro-pyran-3-yl)-3-((1R,2S,3S,4R,5S)-2,3,4,5-tetrahydroxy-2-hydroxymethyl-cyclopentyl)-thiourea 
• 136172-58-2 1,6-di-O-acetyl-2-azido-3,4-di-O-benzyl-2-deoxy-α,β-D-glucopyranose 

Relevant academic research and scientific papers

Preparation method of fondaparinux sodium intermediate

The invention relates to a preparation method of a fondaparinux sodium intermediate, particularly relates to a preparation method of a compound of a formula D5, and further provides a method for preparing fondaparinux sodium from the compound of the formula D5. R and R are hydroxyl protecting groups. According to the preparation methods, a process route is simplified, the synthesis yield isincreased, purification work of subsequent products is simplified, and the overall process production cost is reduced. (Please see the specification for the formula.)

Preparation method of fondaparin sodium intermediate

The invention relates to a preparation method of a fondaparin sodium intermediate. In particular, the invention relates to a preparation method of a compound of formula 3, R1 is an alkyl protecting group or a hydroxy protecting group; and a process for preparation of fondaparin sodium from the compound of formula 3.

Synthesis of α-glucosidase inhibitors: Kojibiose-type pseudodisaccharides and a related pseudotrisaccharide

Two kojibiose-type pseudo-disaccharides and a trisaccharide, containing a 5-amino-1,2,3,4-cyclopentanetetrol derivative or valienamine, linked by way of nitrogen bridges to the sugar residues, have been designed and synthesized as processing α-glucosidase I inhibitors. Synthesis of the pseudodisaccharides was carried out starting from the coupling products of the sugar isothiocyanates and an aminocyclitol, respectively, by cyclization with mercury(II) oxide to the cyclic isoureas and subsequent deprotection. Pseudokojibiose was prepared in a poor yield by reaction of a protected valienamine and a sugar epoxide, followed by deprotection. Although the pseudooligosaccharides are all strong inhibitors of α-glucosidase (baker's yeast), they did not have any inhibitory potency against either sucrase isomaltase (rat Intestine) or processing α-glucosidase (rat liver microsomes).

REACTIVITE DES N-IMIDAZOLYLSULFONATES EN C-2 D'α-D-MANNO- ET GALACTO-PYRANOSIDES

The imidazolylsulfonyl derivatives of methyl 3-O-benzyl-4,6-O-benzylidene-α-D-mannopyranoside, methyl 3,4,6-tri-O-benzyl-α-D-mannopyranoside, a lactose derivative 10 protected everywhere except at OH-2', benzyl 6-O-allyl-3,4-O-isopropylidene-α-D-galactopy