471-32-9

Basic information

• Product Name: Hydrazinecarbodithioicacid (9CI)
• Synonyms: Carbazicacid, dithio- (6CI,7CI); (Dithiocarboxy)hydrazine; Dithiocarbazic acid; NSC132378
• CAS NO: 471-32-9
• Molecular Formula: CH₄N₂S₂
• Molecular Weight: 108.1859
• Mol File: 471-32-9.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 174.1°Cat760mmHg
• Flash Point: 59.1°C
• Density: 1.412g/cm³
• CAS DataBase Reference: Hydrazinecarbodithioicacid (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Hydrazinecarbodithioicacid (9CI)(471-32-9)
• EPA Substance Registry System: Hydrazinecarbodithioicacid (9CI)(471-32-9)

Safety Data

• Hazardous Substances Data: 471-32-9(Hazardous Substances Data)

Upstream product

• 75-15-0 carbon disulfide 
• 26648-11-3 potassium hydrazine carbodithioate 

Downstream Products

• 404594-83-8 bis(mercaptothioformylhydrazido)phthalate 
• 1072-71-5 2,5-Dimercapto-1,3,4-thiadiazole 
• 6610-29-3 4-methylthiosemicarbazide 
• 2231-57-4 Thiocarbohydrazide 
• 34930-11-5 S-(4-methylbenzyl)dithiocarbazate 
• 401641-23-4 2,5-bis(4-methylbenzylthio)-1,3,4-thiadiazole 
• 34930-10-4 S-(2-methylbenzyl)dithiocarbazate 
• 5397-03-5 hydrazinecarbodithioic acid methyl ester 
• 1438-16-0 3-aminorhodanine 
• 5757-37-9 5,5-dimethyl-[1,3,4]thiadiazolidine-2-thione 
• 14673-46-2 5-phenyl-3-aminothiazolidine-2-thion-4-one 

Relevant articles and documents

Preparation process of 4-methylthiosemicarbazide

The invention relates to a preparation process of 4-methylthiosemicarbazide, and belongs to the technical field of pharmaceutical chemicals. The preparation method comprises the following steps: adding hydrazine hydrate into a reaction bottle, dropwise adding carbon disulfide at 20-25 DEG C for 2-3 hours, and keeping the temperature at 20-25 DEG C for 1-2 hours after dropwise adding is finished; controlling the temperature to be 25-30 DEG C, dropwise adding monomethylamine into the reaction bottle for 1-2 hours, introducing nitrogen at the temperature of 70-75 DEG C after dropwise adding is finished, performing refluxing for 1-2 hours, and blowing off hydrogen sulfide gas generated by the reaction; and performing cooling to 0-5 DEG C, performing filtering to obtain an MTSC wet product, carrying out vacuum drying at 55 DEG C for 3 hours, performing heating to 70 DEG C, carrying out vacuum drying for 2-3 hours, and controlling the moisture content to be less than 0.1% to obtain white crystal powder 4-methylthiosemicarbazide. The preparation process is scientific and reasonable in design, wide in raw material source, low in cost, simple in step, green and pollution-free, improves theproduction efficiency, and is beneficial to industrial production.

Synthesis of New N-Benzoyl-N'-Triazine Thiourea Derivatives and Their Antibacterial Activity

Abstract: A series of new N-benzoyl-N'-triazine thiourea derivatives have been synthesized via the reaction of 4-amino-6-methyl-3-thioxo-3,4-dihydro-1,2,4-triazin-5(2H)-one with benzoyl chloride derivatives and ammonium thiocyanate in acetone under reflux conditions. 4-Amino-6-methyl-3-thioxo-3,4-dihydro-1,2,4-triazin-5(2H)-one was prepared from the reaction of two equivalents of hydrazine hydrate with carbon disulfide and sodium pyruvate. The chemical structure of thioureas was confirmed using FT-IR, 1H NMR, 13C NMR, and high-resolution mass spectrometry, and elemental analysis. The synthesized thioureas were assayed for their antibacterial activity against both gram-positive (Micrococcusluteus and Bacilluscereus) and gram-negative (Pseudomonasaeruginosa and Escherichiacoli) bacteria using the agar well diffusion method.

Effect of substitution at N″-position of N′-hydroxy-N-amino guanidines on tumor cell growth

Structural modification of one of our earlier reported lead molecule (ABNM13) has been carried out to study the effect of different substituents at the N″-position of N-hydroxy-N′-amino guanidines (HAGs) on their anticancer activity. Compounds with electron donating substituents were found to be less active. In contrast, those with electron withdrawing groups were found favorable for anticancer activity. The obtained results provide significant SAR information that may be useful for further drug designing with HAGs.