471-87-4

Usage

Uses

Used in Pharmaceutical Industry:
N,N-Dimethyl-L-proline is used as a building block for the synthesis of various pharmaceutical compounds, such as peptidomimetics and peptidic drugs. Its unique structural features allow for the development of novel bioactive molecules with improved stability, selectivity, and bioavailability.
Used in Chemical Research:
N,N-Dimethyl-L-proline is utilized as a chiral auxiliary in asymmetric synthesis, providing a source of chirality to help control the stereochemistry of the target molecules. This application is valuable in the development of enantiomerically pure compounds with potential applications in various industries.
Used in Nutritional Supplements:
N,N-Dimethyl-L-proline may be used as an ingredient in nutritional supplements, potentially offering benefits related to cognitive function, mood regulation, and overall well-being. Its role in these applications is still under investigation, and further research is needed to establish its efficacy and safety.
Used in Cosmetics Industry:
In the cosmetics industry, N,N-Dimethyl-L-proline could be employed as an active ingredient in skincare products, potentially providing anti-aging, moisturizing, or soothing effects. Its incorporation into cosmetic formulations may be based on its ability to interact with proteins and other biomolecules in the skin.

References

Ahmad, Basha, Atta-ur-Rahman, Pak. J. Sci. Ind. Res., 17, 109 (1975)

InChI:InChI=1/C7H13NO2/c1-8(2)5-3-4-6(8)7(9)10/h6H,3-5H2,1-2H3/t6-/m0/s1

Upstream product

• 475-11-6 N-methyl-L-proline 
• 74-88-4 methyl iodide 
• 147-85-3 L-proline 

Downstream Products

• 475-11-6 N-methyl-L-proline 

Relevant academic research and scientific papers

Quaternary ammonium oxidative demethylation: X-ray crystallographic, resonance raman, and uv-visible spectroscopic analysis of a Rieske-type demethylase

Herein, the structure resulting from in situ turnover in a chemically challenging quaternary ammonium oxidative demethylation reaction was captured via crystallographic analysis and analyzed via single-crystal spectroscopy. Crystal structures were determined for the Rieske-type monooxygenase, stachydrine demethylase, in the unliganded state (at 1.6 A resolution) and in the product complex (at 2.2 A resolution). The ligand complex was obtained from enzyme aerobically cocrystallized with the substrate stachydrine (N,N-dimethylproline). The ligand electron density in the complex was interpreted as proline, generated within the active site at 100 K by the absorption of X-ray photon energy and two consecutive demethylation cycles. The oxidation state of the Rieske iron-sulfur cluster was characterized by UV-visible spectroscopy throughout X-ray data collection in conjunction with resonance Raman spectra collected before and after diffraction data. Shifts in the absorption band wavelength and intensity as a function of absorbed X-ray dose demonstrated that the Rieske center was reduced by solvated electrons generated by X-ray photons; the kinetics of the reduction process differed dramatically for the liganded complex compared to unliganded demethylase, which may correspond to the observed turnover in the crystal.

Characterization of amino acid-derived betaines by electrospray ionization tandem mass spectrometry

Betaines belong to the naturally occurring osmoprotectants or compatible solutes present in a variety of plants, animals and microorganisms. In recent years, metabolomic techniques have been emerging as a fundamental tool for biologists because the constellation of these molecules and their relative proportions provide with information about the actual biochemical condition of a biological system. Therefore, identification and characterization of biologically important betaines are crucial, especially for metabolomic studies. Most of the natural betaines are derived from amino acids and related homologues. Although, theoretically, all the amino acids can be converted to corresponding betaines by simple methylation of the amine group, only a few of the amino acid-derived betaines were fully characterized in the literature. Here, we report a combined electrospray ionization tandem and high-resolution mass spectrometry study of all the betaines derived from amino acids, including the isomeric betaines. The decomposition pathway of protonated, sodiated and potassiated molecule ions that enable unambiguous characterization of the betaines including the isomeric betaines and overlapping ionic species of different betaines is distinctive. Copyright