471239-63-1

Basic information

• Product Name: 4-(2-thienyl)-1,2-Benzenediamine
• Synonyms: 4-(2-thienyl)-1,2-Benzenediamine
• CAS NO: 471239-63-1
• Molecular Weight: 190.269
• Mol File: 471239-63-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4-(2-thienyl)-1,2-Benzenediamine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-thienyl)-1,2-Benzenediamine(471239-63-1)
• EPA Substance Registry System: 4-(2-thienyl)-1,2-Benzenediamine(471239-63-1)

Safety Data

• Hazardous Substances Data: 471239-63-1(Hazardous Substances Data)

Upstream product

• 849235-53-6 2-nitro-5-thiophen-2-yl-phenylamine 
• 5228-61-5 5-bromo-2-nitroaniline 
• 405170-93-6 2-nitro-4-thiophen-2-yl-phenylamine 

Downstream Products

• 1070671-52-1 benzyl 3-(2-amino-4-(thiophen-2-yl)phenylamino)-3-oxo-2-phenylpropanoate 

Relevant articles and documents

Synthesis and Antimicrobial Activity of Novel Substituted 4-[3-(1H-Benzimidazol-2-yl)-4-hydroxybenzyl]-2-(1H-benzimidazol-2-yl)phenol Derivatives

A series of novel substituted bis-benzimidazole derivatives were synthesized by reaction of 5,5′-methylenebis(2-hydroxybenzaldehyde) with various substituted o-phenylenediamines in glacial acetic acid. The structure of the newly synthesized compounds was elucidated by 1H and 13C NMR, FT-IR, and MS spectra, and their antimicrobial activity against gram positive and gram negative bacteria and antifungal activity were evaluated. The thienyl-substituted derivative showed significant activity against Bacillus licheniformis, Bacillus subtilis, Staphylococcus aureus, Klebsiella pneumonia (bacteria), and Fusarium solani (fungi). The activities of the fluoro-substituted substituted derivative against some bacterial strains and of the thienyl-substituted derivative against fungi were found to be similar to those of standard drugs.

INHIBITORS OF HISTONE DEACETYLASE

This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula compounds of the Formula (I) and N-oxides, hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof, and racemic and scalemic mixtures, diastereomers and enantiomers thereof, wherein groups L, M, X and Y are as defined herein.