4718-05-2Relevant academic research and scientific papers
Identification of 2(1H)-pyrimidinones as potential EGFR T790M inhibitors for the treatment of gefitinib-resistant non-small cell lung cancer
Huang, Jianping,Huang, Jiaxin,Wang, Ning,Wang, Luhong,Li, Lei,Wang, Changyuan,Sun, Xiuli,Li, Yongming,Huang, Guoping,Ma, Xiaodong
, (2019)
A new class of 2(1H)-pyrimidinone derivatives was identified as potential EGFR T790M inhibitors against TKI-resistant NSCLC. These novel compounds inhibited the EGFR T790M kinase activity at concentrations in the range of 85.3 to 519.9 nM. In particular,
