4728-90-9

Usage

Uses

Used in Fragrance Industry:
Spiro[5.6]dodecan-7-one is used as a fragrance ingredient in perfumes and other cosmetic products for its appealing and fruity scent, enhancing the sensory experience of these products.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, Spiro[5.6]dodecan-7-one serves as a key intermediate in the synthesis of various biologically active compounds, contributing to the development of new medications and therapies.
Used in Organic Chemistry:
As a versatile building block in organic chemistry, Spiro[5.6]dodecan-7-one is utilized in the development of novel materials and drug molecules, showcasing its potential in advancing scientific research and applications.

InChI:InChI=1/C12H20O/c13-11-7-3-1-4-8-12(11)9-5-2-6-10-12/h1-10H2

Upstream product

• 2888-11-1 1,1'-bicyclohexane-1,1'-diol 
• 106165-15-5 spiro[5.6]dodec-2-en-7-one 
• 6558-81-2 ethyl N-nitroso-N-cyclohexylcarbamate 
• 108-94-1 cyclohexanone 
• 111-24-0 1,5-dibromo-pentane 
• 502-42-1 cycloheptanone 
• 1189-71-5 isocyanate de chlorosulfonyle 
• 19009-71-3 1,1'-Bis-trimethylsiloxy-bicyclohexyl 
• 186581-53-3 diazomethane 
• 1781-83-5 spiro[5.5]undecan-1-one 
• 120-92-3 cyclopentanone 
• 1541-19-1 ethyl N-cyclohexylcarbamate 
• 60274-60-4 1-chloro-5-iodopentane 
• 14300-09-5 N-cyclohexyl-N-nitroso-acetamide 

Downstream Products

• 5632-26-8 [1,1';1',1'';1'',1''']quatercyclohexane 
• 1130-20-7 Spiro<5.6>dodecan-7-ol 
• 181-15-7 Spiro<5.6>dodecan 

Relevant academic research and scientific papers

Renewable high-density spiro-fuels from lignocellulose-derived cyclic ketones

Renewable high-density spiro-fuels are synthesized from lignocellulose-derived cyclic ketones for the first time, which show higher density, higher neat heat of combustion and lower freezing point compared with other biofuels synthesized from the same feedstock, and thus represent a new type of renewable high-density fuel attractive for practical applications.

Palladium catalyzed synthesis of some novel (Spirocycloalkenyl) trimethylsilylacetylenes

The synthesis of some novel (spirocycloalkenyl)trimethylsilylacetylenes employing the Sonogashira coupling reaction of the corresponding novel spirocycloalkenyliodides with trimethylsilylacetylene and Pd(PPh3)2Cl2/CuI catalyst in yields ranging 79-84% is reported. The compounds would serve as novel (spirocycloalkenyl)acetylenic anionic synthons.

Macrocyclic Spiro Pyrimidine Derivatives

Macrocyclic spiro pyrimidine compounds, compositions comprising such compounds, methods for making the compounds, and methods of treating and preventing the progression of diseases, conditions, and disorders using such compounds and compositions are described herein.

Non-dehydrative pinacol rearrangement using a Lewis acid-trialkyl orthoester combined system

An efficient pinacol rearrangement mediated by trialkyl orthoformate has been developed. The reactions of various types of diols with a catalytic amount of a Lewis acid in the presence of an orthoester afforded the rearranged product in good yields via a cyclic orthoester intermediate. This combined system is applicable not only to cyclic and acyclic tri- and tetra- substituted diols but also to the diols having acid-sensitive acetals.

Study of I-strain relief in the intermediate when forming spiro ketones from unsymmetrical cycloalkylidenecycloalkanes, their dibromides, and their pinacols

Three unsymmetrical intercyclic olefins, their dibromides, and their pinacols were prepared, each so the two carbons involved at the functional group were part of a different sized ring. The pinacols were reacted with 25% sulfuric acid and with boron trif

The Catalytic Pinacol Rearrangement of 1,2-Diols Using an Antimony(V)Salt

In the presence of a catalytic amount of antimony(V)chloride or antimony(V)salt generated from antimony(V)chloride and silver hexafluoroantimonate, the pinacol rearrangement of several 1,2-diols or their trimethylsilyl ethers proceeds smoothly to give the corresponding ketones in good yields.

REACTION OF CHLOROSULFONYL ISOCYANATE WITH 1,2-DIOLS: REARRANGEMENT AND FORMATION OF CARBONATES

1,2-Diols, 1a-e, upon reaction with chlorosulfonyl isocyanate (CSI) gave the ketones, 3a-e.Under similar experimental conditions, 1,2-diols, 1f-k, gave carbonyl compounds, 3f-k, carbonates, 6f-k, carboxamides, 7h,i, and the epoxide, 5i.

ORIGINAL METHOD FOR THE RING ENLARGEMENT OF CYCLIC KETONES

Thallium ethoxide in chloroform was found to be a particularly valuable combination for the rearrangement of β-hydroxyselenides to ketones.

Carbenoids by Deoxygenation of Carbonyl Compounds with Chloromethylsilanes

Deoxygenation of benzophenone, benzaldehyde, and cyclohexanone with chloromethylsilanes and zinc-copper couple in ether is reported to yield 2,2,2-triphenylacetophenone, a mixture of deoxybenzoin and diphenylacetaldehyde, and a bicyclic ketone with the proposed 2-oxocycloheptanespirocyclohexane structure, respectively; a carbene mechanism is proposed.