472968-70-0

Basic information

• Product Name: (2R,3R)-2-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-3-(4-fluoro-phenyl)-4-((R)-1-phenyl-ethyl)-morpholine
• Synonyms: (2R,3R)-2-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-3-(4-fluoro-phenyl)-4-((R)-1-phenyl-ethyl)-morpholine
• CAS NO: 472968-70-0
• Molecular Weight: 541.509
• Mol File: 472968-70-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2R,3R)-2-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-3-(4-fluoro-phenyl)-4-((R)-1-phenyl-ethyl)-morpholine(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3R)-2-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-3-(4-fluoro-phenyl)-4-((R)-1-phenyl-ethyl)-morpholine(472968-70-0)
• EPA Substance Registry System: (2R,3R)-2-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-3-(4-fluoro-phenyl)-4-((R)-1-phenyl-ethyl)-morpholine(472968-70-0)

Safety Data

• Hazardous Substances Data: 472968-70-0(Hazardous Substances Data)

Usage

General Description

The chemical (2R,3R)-2-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-3-(4-fluoro-phenyl)-4-((R)-1-phenyl-ethyl)-morpholine is a complex, multi-substituted morpholine derivative. It contains a morpholine ring with two substituents - one a 3,5-bis-trifluoromethyl-phenyl-ethoxy group and the other a 4-fluoro-phenyl group. Additionally, there is a (R)-1-phenyl-ethyl substituent attached to the morpholine ring. The chemical structure features stereochemistry at the 2, 3, and (R)-centers, and the presence of fluorine atoms adds to the chemical's reactivity and potential pharmacological properties. This molecule may have potential therapeutic applications due to its unique structure and multiple functional groups.

Upstream product

• 447-43-8 1-(4-fluorophenyl)-2,2-dihydroxyethan-1-one 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 80548-31-8 (R)-(+)-N-(2-hydroxyethyl)-α-phenylethylamine 
• 30071-93-3 3,5-bis(trifluoromethyl)phenyl methyl ketone 
• 368-63-8 (R)-[3,5-bis(trifluoromethyl)phenyl]ethanol 
• 472968-69-7 2,2,2-Trichloro-acetimidic acid (2R,3R)-3-(4-fluoro-phenyl)-4-((R)-1-phenyl-ethyl)-morpholin-2-yl ester 
• 472968-68-6 (2S,3R)-3-(4-fluorophenyl)-4-[(1R)-1-phenylethyl]-2-morpholinol 

Downstream Products

• 380499-07-0 (2R)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-5,6-dihydro-2H-1,4-oxazine 
• 171338-27-5 [2R-[2α(R*),3α]]-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine 
• 170729-80-3 aprepitant 
• 171482-05-6 (2R,3R)-2-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-3-(4-fluoro-phenyl)-morpholine; hydrochloride 
• 380499-06-9 (2R,3R)-2-[(1R)-1-(3,5-bis-trifluoro-methylphenyl)ethoxy]-3-(4-fluorophenyl)morpholine 

Relevant articles and documents

Preparation methods of aprepitant impurity

The invention discloses preparation methods of an aprepitant impurity, which comprise isomer impurity synthesis method of six aprepitant key intermediates (2R, 3S)-2-[(1R)-1-[3, 5-bis (trifluoromethyl)-phenyl] ethoxy]-3-(4-fluorophenyl) morpholine, respectively, synthesis of four diastereomer impurities, synthesis of one enantiomer impurity and synthesis of one by-product impurity. The methods have the beneficial effects that the five synthesis methods are simple and feasible, the raw materials are easy to obtain, the conditions are mild, the cost is low, the production is facilitated, and meanwhile, the isomer impurities of the synthesized aprepitant key intermediate provide a new intermediate raw material for the preparation of aprepitant.