4736-71-4

Usage

Uses

Used in Skin and Hair Care Products:
PYRROLIDINE-1-CARBOXYLIC ACID AMIDE is used as a moisturizing and antioxidant agent in skin and hair care products for its ability to enhance hydration and provide protection against oxidative stress, contributing to healthier and more resilient skin and hair.
Used in Pharmaceutical Applications:
In the pharmaceutical industry, PYRROLIDINE-1-CARBOXYLIC ACID AMIDE is utilized as a chelating agent, which helps in the binding and removal of metal ions, thus playing a crucial role in detoxification processes and the development of certain drugs.
Used in the Production of Certain Drugs:
PYRROLIDINE-1-CARBOXYLIC ACID AMIDE is also employed in the manufacturing process of specific pharmaceuticals, leveraging its unique chemical properties to contribute to the efficacy and function of these medications.
Overall, the versatility of PYRROLIDINE-1-CARBOXYLIC ACID AMIDE in various applications underscores its importance in multiple industries, from cosmetics to pharmaceuticals, where it contributes to product performance and health benefits.

InChI:InChI=1/C5H10N2O/c6-5(8)7-3-1-2-4-7/h1-4H2,(H2,6,8)

Upstream product

• 123-75-1 pyrrolidine 
• 57-13-6 urea 
• 143-33-9 sodium cyanide 
• 1530-88-7 pyrrolidine-1-carbonitrile 
• 103772-04-9 N-carbamoyl-2-methoxypyrrolidine 
• 62969-93-1 Pyrrolidine-1-carboximidic acid 1-ethynyl-butyl ester 
• 62969-88-4 4-octyn-3-yl 1-pyrrolidinecarboximidate 
• 62969-89-5 Pyrrolidine-1-carboximidic acid 1-butyl-hex-2-ynyl ester 
• 62969-90-8 Pyrrolidine-1-carboximidic acid 1-benzyl-4,4-dimethyl-pent-2-ynyl ester 
• 110-56-5 1,4-dichlorobutane 
• 590-28-3 potassium cyanate 
• 25150-61-2 pyrrolidine hydrochloride 
• 622-46-8 carbamic acid phenyl ester 

Downstream Products

• 104417-80-3 Pyrrolidine-1-carboxylic acid bis-(3,5-dichloro-benzoyl)-amide 
• 104431-07-4 Pyrrolidine-1-carboxylic acid bis-(4-ethoxy-benzoyl)-amide 
• 87454-58-8 Picric acid; compound with pyrrolidine-1-carboxylic acid amide 
• 104417-78-9 Pyrrolidine-1-carboxylic acid dibenzoylamide 
• 1530-88-7 pyrrolidine-1-carbonitrile 
• 19055-93-7 1,3-diazepan-2-one 
• 3389-54-6 n-benzoylpyrrolidine 
• 259538-82-4 (2 R)-1-Cyclopentyl-2-pyrrolidinecarboxamide 
• 259538-92-6 (2 R)-1-[(1-Methylcyclopropyl)methyl]-2-pyrrolidinecarboxamide 

Relevant academic research and scientific papers

Catalytic hydration of cyanamides with phosphinous acid-based ruthenium(ii) and osmium(ii) complexes: scope and mechanistic insights

The synthesis of a large variety of ureas R1R2NC(O)NH2 (R1 and R2 = alkyl, aryl or H; 26 examples) was successfully accomplished by hydration of the corresponding cyanamides R1R2NCN using the phosphinous acid-based complexes [MCl2(η6-p-cymene)(PMe2OH)] (M = Ru (1), Os (2)) as catalysts. The reactions proceeded cleanly under mild conditions (40-70 °C), in the absence of any additive, employing low metal loadings (1 molpercent) and water as the sole solvent. In almost all the cases, the osmium complex 2 featured a superior reactivity in comparison to that of its ruthenium counterpart 1. In addition, for both catalysts, the reaction rates observed for the hydration of the cyanamide substrates were remarkably faster than those involving classical aliphatic and aromatic nitriles. Computational studies allowed us to rationalize all these trends. Thus, the calculations indicated that the presence of a nitrogen atom directly linked to the CN bond depopulates electronically the nitrile carbon by inductive effect when coordinated to the metal center, thus favouring the intramolecular nucleophilic attack of the OH group of the phosphinous acid ligand to this carbon. On the other hand, the higher reactivity of Os vs. Ru seems to be related with the lower ring strain on the incipient metallacycle that starts to form in the transition state associated with this key step in the catalytic cycle. Indirect experimental evidence of the generation of the metallacyclic intermediates was obtained by studying the reactivity of [RuCl2(η6-p-cymene)(PMe2OH)] (1) towards dimethylcyanamide in methanol and ethanol. The reactions afforded compounds [RuCl(η6-p-cymene)(PMe2OR)(NCNMe2)][SbF6] (R = Me (5a), Et (5b)), resulting from the alcoholysis of the metallacycle, which could be characterized by single-crystal X-ray diffraction. This journal is

TYK2 INHIBITORS AND USES THEREOF

Described herein are compounds that are useful in treating a TYK2-mediated disorder. In some embodiments, the TYK2-mediated disorder is an autoimmune disorder, an inflammatory disorder, a proliferative disorder, an endocrine disorder, a neurological disorder, or a disorder associated with transplantation.

Regioselective Formal [3+2] Cycloadditions of Urea Substrates with Activated and Unactivated Olefins for Intermolecular Olefin Aminooxygenation

A new class of intermolecular olefin aminooxygenation reaction is described. This reaction utilizes the classic halonium intermediate as a regio- and stereochemical template to accomplish the selective oxyamination of both activated and unactivated alkenes. Notably, urea chemical feedstock can be directly introduced as the N and O source and a simple iodide salt can be utilized as the catalyst. This formal [3+2] cycloaddition process provides a highly modular entry to a range of useful heterocyclic products with excellent selectivity and functional-group tolerance.

A Physical Organic Approach to Tuning Reagents for Selective and Stable Methionine Bioconjugation

We report a data-driven, physical organic approach to the development of new methionine-selective bioconjugation reagents with tunable adduct stabilities. Statistical modeling of structural features described by intrinsic physical organic parameters was applied to the development of a predictive model and to gain insight into features driving the stability of adducts formed from the chemoselective coupling of oxaziridine and methionine thioether partners through Redox Activated Chemical Tagging (ReACT). From these analyses, a correlation between sulfimide stabilities and sulfimide ν (C=O) stretching frequencies was revealed. We exploited the rational gains in adduct stability exposed by this analysis to achieve the design and synthesis of a bis-oxaziridine reagent for peptide stapling. Indeed, we observed that a macrocyclic peptide formed by ReACT stapling at methionine exhibited improved uptake into live cells compared to an unstapled congener, highlighting the potential utility of this unique chemical tool for thioether modification. This work provides a template for the broader use of data-driven approaches to bioconjugation chemistry and other chemical biology applications.

N-Acyl-N'-(pyridin-2-yl) Ureas and Analogs Exhibiting Anti-Cancer and Anti-Proliferative Activities

Described are compounds of Formula 1 which find utility in the treatment of cancer, autoimmune diseases and metabolic bone disorders through inhibition of c-FMS (CSF-1R), c-KIT, and/or PDGFR kinases. These compounds also find utility in the treatment of other mammalian diseases mediated by c-FMS, c-KIT, or PDGFR kinases.

Process for the preparation of asymmetrically substituted ureas

Process for the preparation of asymmetrically substituted ureas by reaction of a gaseous mixture of isocyanic acid and ammonia having a temperature of 260° to 600° C. with a primary or secondary amine.

HYDROGEN BONDED COMPLEXES IV; UREA-PHENOL COMPLEXES

A number of crystalline, hydrogen-bonded complexes of ureas and phenols are reported.The most commonly observed urea-phenol ratio is 1:1, but some complexes with ratios of 2:1, 1:2 and 1:3 were encountered.The structures of these complexes are discussed and one degradative reaction is described.

Organic compounds substituted heptadeca-5,9- and 5,10-dienoic acid

The present invention provides novel substituted heptadeca-5,9- and 5,10-dienoic acid and similar fatty acid compounds which are derivatives of certain prostaglandins and are potent thromboxane A2 inhibitors. By virtue of this pharmacological property, they represent useful pharmacological agents for a wide variety of purposes.