473706-10-4

Basic information

• Product Name: 4-(4-Fluorophenyl)tetrahydro-2H-pyran-4-carbonitrile
• CAS NO: 473706-10-4
• Molecular Weight: 205.232
• Mol File: 473706-10-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4-(4-Fluorophenyl)tetrahydro-2H-pyran-4-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-Fluorophenyl)tetrahydro-2H-pyran-4-carbonitrile(473706-10-4)
• EPA Substance Registry System: 4-(4-Fluorophenyl)tetrahydro-2H-pyran-4-carbonitrile(473706-10-4)

Safety Data

• Hazardous Substances Data: 473706-10-4(Hazardous Substances Data)

Upstream product

• 135420-00-7 (4-fluoromethyl-phenyl)-acetonitrile 
• 111-44-4 3-oxa-1,5-dichloropentane 
• 5414-19-7 1,1'-oxybis(2-bromo-ethane) 
• 459-22-3 4-fluorophenylacetonitrile 

Downstream Products

• 1338349-10-2 1-benzyl-N-{[4-(4-fluorophenyl)tetrahydro-2H-pyran-4-yl]methyl}piperidine-4-carboxamide hydrochloride 
• 889939-79-1 C₁₂H₁₆FNO 
• 1338349-02-2 tert-butyl 4-({[4-(4-fluorophenyl)tetrahydro-2H-pyran-4-yl]methyl}carbamoyl)piperidine-1-carboxylate 

Relevant articles and documents

INHIBITOR OF INDOLEAMINE-2,3-DIOXYGENASE (IDO)

The present disclosure provides compounds of Formula (I). The compounds described herein may be useful in treating a disease associated with IDO, for example, cancer or an infectious disease (e.g., viral or bacterial infectious diseases). Also, provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including or using a compound described herein.

Synthesis and pharmacological evaluation of 1-alkyl-N-[2-ethyl-2-(4- fluorophenyl)butyl]piperidine-4-carboxamide derivatives as novel antihypertensive agents

We synthesized and evaluated inhibitory activity against T-type Ca 2+ channels for a series of 1-alkyl-N-[2-ethyl-2-(4-fluorophenyl) butyl]piperidine-4-carboxamide derivatives. Structure-activity relationship studies have revealed that dialkyl substituents at the benzylic position play an important role in increasing inhibitory activity. Oral administration of N-[2-ethyl-2-(4-fluorophenyl)butyl]-1-(2-phenylethyl)piperidine-4-carboxamide (20d) lowered blood pressure in spontaneously hypertensive rats without inducing reflex tachycardia, which is often caused by traditional L-type Ca2+ channel blockers.