473719-41-4

Usage

Uses

Used in Pharmaceutical Industry:
AMG 487 is used as a therapeutic agent for the treatment of autoimmune and inflammatory diseases. By selectively blocking the CXCR3 receptor, it modulates the immune response and reduces inflammation, offering potential benefits in managing conditions such as multiple sclerosis, rheumatoid arthritis, and inflammatory bowel disease.
Used in Research Applications:
AMG 487 is used as a research tool for studying the role of CXCR3 in immune responses and disease mechanisms. It helps researchers to understand the molecular pathways and interactions involved in various inflammatory and autoimmune conditions, facilitating the development of novel therapeutic strategies and drug targets.

Upstream product

• 947536-02-9 rac-3-(4-ethoxy-phenyl)-2-{1-[(pyridin-3-ylmethyl)-amino]-ethyl}-3H-pyrido[2,3-d]pyrimidin-4-one 
• 4315-07-5 4-(trifluoromethoxy)phenylacetic acid 
• 156-43-4 4-Ethoxyaniline 
• 752244-96-5 C₁₇H₁₈N₄O₂ 
• 752244-95-4 (R)-{1-[3-(4-ethoxy-phenyl)-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-2-yl]-ethyl}-carbamic acid tert-butyl ester 
• 473720-90-0 (R)-{1-[3-(4-ethoxy-phenylcarbamoyl)-pyridin-2-ylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester 
• 473720-89-7 (R)-[1-(4-oxo-4H-pyrido[2,3-d][1,3]oxazin-2-yl)-ethyl]-carbamic acid tert-butyl ester 
• 473720-92-2 C₂₃H₂₃N₅O₂ 
• 5345-47-1 2-aminopyridin-3-carboxylic acid 
• 947536-13-2 rac-2-(1-amino-ethyl)-3-(4-ethoxy-phenyl)-3H-pyrido[2,3-d]pyrimidin-4-one 

Relevant academic research and scientific papers

Synthesis and Application of the First Radioligand Targeting the Allosteric Binding Pocket of Chemokine Receptor CXCR3

Strategies for the identification of allosteric modulators of chemokine receptors largely rely on various cell-based functional assays. Radioligand binding assays are typically not available for allosteric binding sites. We synthesized, purified, and appl

Discovery and optimization of a series of quinazolinone-derived antagonists of CXCR3

A series of quinazolinone-derived inhibitors of the CXCR3 receptor have been synthesized and their affinity for the receptor evaluated. Compounds were evaluated in a 125I-IP10 displacement assay and in in vitro cell migration assays to IP10, IT

Synthesis and structure-activity relationships of 3H-quinazolin-4-ones and 3H-pyrido[2,3-d]pyrimidin-4-ones as CXCR3 receptor antagonists

CXC chemokine receptor-3 (CXCR3) is a G-protein coupled receptor (GPCR) predominantly expressed on activated T lymphocytes that promote Th1 responses. Previously, we described the 3H-quinazolin-4-one containing VUF 5834 (decanoic acid {1-[3-(4-cyano-pheny