947536-13-2

Upstream product

• 156-43-4 4-Ethoxyaniline 
• 947536-07-4 C₂₂H₂₆N₄O₄ 
• 5345-47-1 2-aminopyridin-3-carboxylic acid 
• 473720-90-0 (R)-{1-[3-(4-ethoxy-phenylcarbamoyl)-pyridin-2-ylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester 
• 473720-89-7 (R)-[1-(4-oxo-4H-pyrido[2,3-d][1,3]oxazin-2-yl)-ethyl]-carbamic acid tert-butyl ester 

Downstream Products

• 473719-41-4 (+/-)-AMG₄₈₇ 
• 855527-92-3 (+/-)-NBI-74330 
• 1397708-92-7 N-{1-[3-(4-ethoxyphenyl)-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl]ethyl}-2-[4-fluoro-3-(trifluoromethyl)phenyl]-N-(piperidin-4-ylmethyl)acetamide 
• 1397708-93-8 N-{1-[3-(4-ethoxyphenyl)-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl]ethyl}-2-[4-fluoro-3-(trifluoromethyl)phenyl]-N-[(1-methylpiperidin-4-yl)methyl]acetamide 
• 1397708-94-9 [3H]-RAMX₃ 
• 1397708-90-5 tert-butyl 4-[({1-[3-(4-ethoxyphenyl)-4-oxo-3,4-dihydropyrido-[2,3-d]pyrimidin-2-yl]ethyl}amino)methyl]piperidine-1-carboxylate 

Relevant academic research and scientific papers

Synthesis and Application of the First Radioligand Targeting the Allosteric Binding Pocket of Chemokine Receptor CXCR3

Strategies for the identification of allosteric modulators of chemokine receptors largely rely on various cell-based functional assays. Radioligand binding assays are typically not available for allosteric binding sites. We synthesized, purified, and appl

Synthesis and structure-activity relationships of 3H-quinazolin-4-ones and 3H-pyrido[2,3-d]pyrimidin-4-ones as CXCR3 receptor antagonists

CXC chemokine receptor-3 (CXCR3) is a G-protein coupled receptor (GPCR) predominantly expressed on activated T lymphocytes that promote Th1 responses. Previously, we described the 3H-quinazolin-4-one containing VUF 5834 (decanoic acid {1-[3-(4-cyano-pheny