947536-02-9

Upstream product

• 500-22-1 3-pyridinecarboxaldehyde 
• 947536-13-2 rac-2-(1-amino-ethyl)-3-(4-ethoxy-phenyl)-3H-pyrido[2,3-d]pyrimidin-4-one 
• 5345-47-1 2-aminopyridin-3-carboxylic acid 
• 752244-95-4 (R)-{1-[3-(4-ethoxy-phenyl)-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-2-yl]-ethyl}-carbamic acid tert-butyl ester 
• 473720-90-0 (R)-{1-[3-(4-ethoxy-phenylcarbamoyl)-pyridin-2-ylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester 
• 473720-89-7 (R)-[1-(4-oxo-4H-pyrido[2,3-d][1,3]oxazin-2-yl)-ethyl]-carbamic acid tert-butyl ester 

Downstream Products

• 473719-41-4 (+/-)-AMG₄₈₇ 
• 855527-92-3 (+/-)-NBI-74330 

Relevant academic research and scientific papers

Synthesis and structure-activity relationships of 3H-quinazolin-4-ones and 3H-pyrido[2,3-d]pyrimidin-4-ones as CXCR3 receptor antagonists

CXC chemokine receptor-3 (CXCR3) is a G-protein coupled receptor (GPCR) predominantly expressed on activated T lymphocytes that promote Th1 responses. Previously, we described the 3H-quinazolin-4-one containing VUF 5834 (decanoic acid {1-[3-(4-cyano-pheny