473871-20-4Relevant academic research and scientific papers
Rapid access towards follow-up NOP receptor agonists using a knowledge based approach
Palin, Ronald,Clark, John K.,Evans, Louise,Feilden, Helen,Fletcher, Dan,Hamilton, Niall M.,Houghton, Andrea K.,Jones, Philip S.,McArthur, Duncan,Montgomery, Brian,Ratcliffe, Paul D.,Smith, Alasdair R.C.,Sutherland, Aaron,Weston, Mark A.,Wishart, Grant
scheme or table, p. 6441 - 6446 (2010/05/02)
A knowledge based approach has been adopted to identify novel NOP receptor agonists with simplified hydrophobes. Substitution of the benzimidazol-2-one piperidine motif with a range of hydrophobic groups and pharmacophore guided bio-isosteric replacement
Potent 1,3,4-trisubstituted pyrrolidine CCR5 receptor antagonists: Effects of fused heterocycles on antiviral activity and pharmacokinetic properties
Kim, Dooseop,Wang, Liping,Hale, Jeffrey J.,Lynch, Christopher L.,Budhu, Richard J.,MacCoss, Malcolm,Mills, Sander G.,Malkowitz, Lorraine,Gould, Sandra L.,Demartino, Julie A.,Springer, Martin S.,Hazuda, Daria,Miller, Michael,Kessler, Joseph,Hrin, Renee C.,Carver, Gwen,Carella, Anthony,Henry, Karen,Lineberger, Janet,Schleif, William A.,Emini, Emilio A.
, p. 2129 - 2134 (2007/10/03)
A series of 1,3,4-trisubstituted pyrrolidine CCR5 receptor antagonists containing a variety of fused heterocycles at the 4-position of the piperidine side chain has been discovered, which are orally bioavailable with potent anti-HIV activity.
1,3-Dihydro-2,1,3-benzothiadiazol-2,2-diones and 3,4-dihydro-1H-2,1,3- benzothidiazin-2,2-diones as ligands for the NOP receptor
Goehring, R. Richard,Whitehead, John F.W.,Brown,Islam, Khondaker,Wen, Xin,Zhou, Xiaoming,Chen, Zhengming,Valenzano, Kenneth J.,Miller, Wendy S.,Shan, Shen,Kyle, Donald J.
, p. 5045 - 5050 (2007/10/03)
A series of 1,3-dihydro-2,1,3-benzothiadiazol-2,2-diones (I) and 3,4-dihydro-1H-2,1,3-benzothidiazin-2,2-diones (II) were prepared. While the five-member ring series (I) did not show good affinity for opioid receptors, the six-member ring series (II) exhi
