98767-79-4Relevant academic research and scientific papers
1,3-Dihydro-2,1,3-benzothiadiazol-2,2-diones and 3,4-dihydro-1H-2,1,3- benzothidiazin-2,2-diones as ligands for the NOP receptor
Goehring, R. Richard,Whitehead, John F.W.,Brown,Islam, Khondaker,Wen, Xin,Zhou, Xiaoming,Chen, Zhengming,Valenzano, Kenneth J.,Miller, Wendy S.,Shan, Shen,Kyle, Donald J.
, p. 5045 - 5050 (2004)
A series of 1,3-dihydro-2,1,3-benzothiadiazol-2,2-diones (I) and 3,4-dihydro-1H-2,1,3-benzothidiazin-2,2-diones (II) were prepared. While the five-member ring series (I) did not show good affinity for opioid receptors, the six-member ring series (II) exhi
DIPHENYLBUTYPIPERIDINE AUTOPHAGY INDUCERS
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Page/Page column 8; 87-90, (2011/12/02)
Autophagy inducing compounds, methods of their preparation and use, and kits containg said compounds are disclosed herein.
Rapid access towards follow-up NOP receptor agonists using a knowledge based approach
Palin, Ronald,Clark, John K.,Evans, Louise,Feilden, Helen,Fletcher, Dan,Hamilton, Niall M.,Houghton, Andrea K.,Jones, Philip S.,McArthur, Duncan,Montgomery, Brian,Ratcliffe, Paul D.,Smith, Alasdair R.C.,Sutherland, Aaron,Weston, Mark A.,Wishart, Grant
scheme or table, p. 6441 - 6446 (2010/05/02)
A knowledge based approach has been adopted to identify novel NOP receptor agonists with simplified hydrophobes. Substitution of the benzimidazol-2-one piperidine motif with a range of hydrophobic groups and pharmacophore guided bio-isosteric replacement
