473918-48-8

Basic information

• Product Name: Benzenamine, 2-(1H-indol-1-yl)-
• CAS NO: 473918-48-8
• Molecular Formula: C14H12N2
• Molecular Weight: 208.263
• Mol File: 473918-48-8.mol
• Article Data: 35

Chemical Properties

• CAS DataBase Reference: Benzenamine, 2-(1H-indol-1-yl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenamine, 2-(1H-indol-1-yl)-(473918-48-8)
• EPA Substance Registry System: Benzenamine, 2-(1H-indol-1-yl)-(473918-48-8)

Safety Data

• Hazardous Substances Data: 473918-48-8(Hazardous Substances Data)

Upstream product

• 120-72-9 indole 
• 615-43-0 2-iodophenylamine 
• 615-36-1 2-bromoaniline 
• 61798-24-1 (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane 
• 29289-13-2 2-iodo-4-methylaniline 
• 614-96-0 5-methyl-1H-indole 
• 3420-02-8 6-methylindole 
• 609-73-4 o-nitroiodobenzene 
• 1493-27-2 ortho-nitrofluorobenzene 
• 25688-25-9 1-(2-nitrophenyl)-1H-indole 

Downstream Products

• 1134136-38-1 6-(4-nitrophenyl)indolo[1,2-a]quinoxaline 
• 1134136-34-7 6-phenylindolo[1,2-a]quinoxaline 
• 1134136-40-5 6-(4-bromophenyl)indolo[1,2-a]quinoxaline 
• 1134136-36-9 N-(4-indolo[1,2-a]quinoxalin-6-ylphenyl)dimethylamine 
• 1226977-95-2 6-phenyl-17bH-indolo[1,2-a]isoquino[1,2-c]quinoxaline 
• 1228076-64-9 Fmoc-Pro-[2-amino Ph-Trp]-OMe 

Relevant articles and documents

Copper-catalyzed N-arylation of amines/amides in poly(ethylene glycol) as recyclable solvent medium

The Buchwald N-arylation of amines and amides is achieved efficiently in PEG (400 Daltons) as solvent medium. The solvent and catalyst recyclability is studied. Interestingly amides underwent N-arylation with better yields. Georg Thieme Verlag Stuttgart.

Cobalt-Catalyzed Direct C-H Carbonylative Synthesis of Free (NH)-Indolo[1,2- a]quinoxalin-6(5 H)-ones

A cobalt-catalyzed direct C-H carbonylative reaction of N-(2-(1H-indol-1-yl)phenyl)picolinamides for the synthesis of (NH)-indolo[1,2-a]quinoxalin-6(5H)-one skeletons has been developed. Using benzene-1,3,5-triyl triformate (TFBen) as the CO source and picolinamide as the traceless directing group, various free (NH)-indolo[1,2-a]quinoxalin-6(5H)-ones were obtained in good yields (up to 88%). Additionally, a series of product derivatizations were demonstrated, and the core fragment of PARP-1 inhibitor C can be readily constructed by this protocol.

Palladium-catalyzed sequential acylation/annulation of indoles with acyl chlorides using primary amine as the directing group

An attractive and convenient strategy for the direct acylation/annulation of indoles has been developed using Pd(0) as an efficient catalyst. The main feature of this protocol is the use of acyl chlorides as the acylating agents with the primary amine as the directing group. A variety of indolo[1,2-a]quinoxalines were readily obtained in reasonable efficiency and satisfactory yields with good functional group tolerance. Based on control experiments, a tentative catalytic mechanism was proposed.