61798-24-1

Basic information

• Product Name: N,N'-Dimethyl-1,2-cyclohexanediamine
• Synonyms: N1,N2-dimethylcyclohexane-1,2-diamine;N,N'-DIMETHYL-1,2-CYCLOHEXANEDIAMINE, 96+ % GC%;Trans-N,N-dimethyle cyclohexane-1,2-diamine;N,N'-Dimethyl-1,2-cyclohexanediamine;N,N’-Dimethyl-cyclohexane-1,2-olamine;RAC-TRANS-N N'-DIMETHYLCYCLOHEXANE-1 2-&;N,N'-Dimethyl-1,2-cyclohexanediamine;N,N'-Dimethyl-1,2-diaminocyclohexane
• CAS NO: 61798-24-1
• Molecular Formula: C₈H₁₈N₂
• Molecular Weight: 142.24
• Product Categories: Nitrogen Compounds;Organic Building Blocks;Polyamines
• Mol File: 61798-24-1.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 78-80 °C18 mm Hg(lit.)
• Flash Point: 165 °F
• Appearance: Clear colorless to slightly yellow liquid
• Density: 0.902 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.472(lit.)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 11.04±0.40(Predicted)
• CAS DataBase Reference: N,N'-Dimethyl-1,2-cyclohexanediamine(CAS DataBase Reference)
• NIST Chemistry Reference: N,N'-Dimethyl-1,2-cyclohexanediamine(61798-24-1)
• EPA Substance Registry System: N,N'-Dimethyl-1,2-cyclohexanediamine(61798-24-1)

Safety Data

• Hazard Codes: C
• Statements: 22-34
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 2735 8/PG 2
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: Ⅱ
• Hazardous Substances Data: 61798-24-1(Hazardous Substances Data)

Usage

Chemical Properties

Clear colorless to slightly yellow liquid

Uses

N,?N''-?Dimethyl-?1,?2-?cyclohexanediamine is used as a catalyst in the synthesis of substituted pyrazoles with anti-inflammatory activity. As well as highly functional pyridines and bipyridines.

Upstream product

• 286-20-4 cyclohexane-1,2-epoxide 
• 20431-81-6 rac-trans-2-methylamino-cyclohexanol 
• 61798-24-1 trans-N,N'-dimethylcyclohexane-1,2-diamine 
• 51066-08-1 7-methyl-7-azabicyclo[4.1.0]heptane 
• 74-89-5 methylamine 
• 1121-22-8 trans-1,2-Diaminocyclohexane 
• 21436-03-3 (S,S)-1,2-diaminocyclohexane 
• 122743-11-7 N-((1S,2S)-2-Formylamino-cyclohexyl)-formamide 
• 942606-10-2 (S,S)-1,2-diaminocyclohexane-N,N'-diethyl carbamate 

Downstream Products

• 68737-65-5 (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane 
• 61798-24-1 (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane 
• 61797-79-3 N,N'-Bis-(10-undecenoyl)-1,2-(N,N'-dimethylamino)-cyclohexan 

Relevant articles and documents

Synthesis and characterization of both enantiomers of a chiral C60 derivative with C2 symmetry

The addition of chiral diamines to C60 allows the synthesis of the two enantiomers of a chiral C60 derivative with C2 symmetry. The circular dichroism spectra of the two isomers show a very intense chirospectroscopic response.

Method for synthesizing trans-cyclohexanedimethanamine

The invention discloses a method for synthesizing trans-cyclohexanedimethanamine, comprising steps of reacting cyclohexene oxide and methylamine aqueous solution under the catalysis of boric acid, and then adding sulfuric acid, dewatering to form an ester, ring-closing under alkaline conditions, adding methylamine aqueous solution and boric acid for hermetic reaction, and distilling to obtain trans-cyclohexanedimethanamine. The synthetic process is simple to perform, provides facilitated isolation and purification and high yield and product purity, and is suitable for batch production.

An efficient synthesis of enantiomerically pure trans-N1,N 2-dimethylcyclohexane-1,2-diamine

A new pathway is described to produce a highly optically pure isomer of trans-N1,N2-dimethylcyclohexane-1,2-diamine through four simple steps. Reaction of cyclohexene oxide with aqueous methylamine, followed by cyclisation with Mitsunobu reagent and ring-opening reactions gave rac-trans-N1,N2-dimethylcyclohexane-1,2-diamine, and the enantiomers were obtained via a kinetic resolution using tartaric acid.