174913-12-3

Basic information

• Product Name: 1-BROMO-3-CHLORO-5-METHOXYBENZENE
• Synonyms: 1-BROMO-3-CHLORO-5-METHOXYBENZENE;3-Bromo-5-chloroanisole;Benzene, 1-bromo-3-chloro-5-methoxy-
• CAS NO: 174913-12-3
• Molecular Formula: C₇H₆BrClO
• Molecular Weight: 221.49
• Mol File: 174913-12-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 236.473 °C at 760 mmHg
• Flash Point: 96.816 °C
• Appearance: /
• Density: 1.564 g/cm³
• Storage Temp.: Room temperature.
• CAS DataBase Reference: 1-BROMO-3-CHLORO-5-METHOXYBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BROMO-3-CHLORO-5-METHOXYBENZENE(174913-12-3)
• EPA Substance Registry System: 1-BROMO-3-CHLORO-5-METHOXYBENZENE(174913-12-3)

Safety Data

• Hazardous Substances Data: 174913-12-3(Hazardous Substances Data)

Usage

General Description

1-Bromo-3-chloro-5-methoxybenzene is a chemical compound with the molecular formula C7H6BrClO. It is a brominated phenol derivative that contains both chlorine and methoxy groups. 1-BROMO-3-CHLORO-5-METHOXYBENZENE is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and organic compounds. It can also be used as a reagent in organic chemistry reactions, including nucleophilic aromatic substitution and cross-coupling reactions. Additionally, 1-bromo-3-chloro-5-methoxybenzene can serve as a building block in the production of dyes, pigments, and polymers. Due to its unique chemical properties, this compound plays a critical role in various industrial and research applications.

InChI:InChI=1S/C7H6BrClO/c1-10-7-3-5(8)2-6(9)4-7/h2-4H,1H3

Upstream product

• 10272-06-7 3-chloro-5-methoxyaniline 
• 6575-00-4 3,5-dichlorobenzonitrile 
• 124-41-4 sodium methylate 
• 929626-16-4 2-(3-chloro-5-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 33863-76-2 1-bromo-3-chloro-5-fluorobenzene 
• 87504-69-6 3-chloro-2,4,5,6-tetrabromophenol 
• 55910-07-1 1-chloro-3-methoxy-5-nitrobenzene 
• 108-43-0 3-monochlorophenol 
• 56962-04-0 3-bromo-5-chlorophenol 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 860734-36-7 5-bromo-3-chloro-2,4-dinitro-anisole 
• 174913-19-0 1-bromo-2,3-dichloro-5-methoxybenzene 
• 214760-34-6 1-(3-chloro-5-methoxyphenyl)ethan-1-one 
• 1257086-27-3 (11β,17α)-17-{[(cyanomethyl)thio]carbonyl}-9-fluoro-11-hydroxy-3-oxoandrosta-1,4-dien-17-yl 4-[(4-chloro-3-hydroxyphenyl)thio]benzoate 
• 1257087-40-3 4-[(3-acetoxy-4-chlorophenyl)thio]benzoic acid 
• 1257087-38-9 4-[(4-chloro-3-methoxyphenyl)thio]benzoic acid 
• 1257087-39-0 4-[(4-chloro-3-hydroxyphenyl)thio]benzoic acid 
• 65262-96-6 3-chloro-5-methoxyphenol 

Relevant articles and documents

Meta halogenation of 1,3-disubstituted arenes via iridium-catalyzed arene borylation

We report the meta halogenation of 1,3-disubstituted arenes to form 3,5-disubstituted aryl bromides and chlorides by using iridium-catalyzed arene borylation chemistry. Iridium-catalyzed borylation of arenes with B2pin2, followed by reaction of the boronic ester with copper(II) bromide or chloride converts arylboronic esters to the corresponding aryl halides. A variety of arenes containing alkoxy, alkyl, halogen, nitrile, ester, amide, and pivaloyl and TIPS-protected alcohols were converted to the corresponding 3,5-disubstituted aryl bromides and chlorides in yields ranging from 46% to 85%. In addition, 2,6-disubstituted and 3-substituted pyridines were converted to the 4-halo and 5-halopyridines, respectively. The utility of this methodology was demonstrated by the formal conversion of nicotine to Altinicline in three steps with an overall yield of 61% using meta bromination of nicotine as the first step. Copyright

Pyrazole derivatives

This invention relates to pyrazole derivatives of formula (I) or pharmaceutically acceptable salts, solvates or derivatives thereof, and to processes for the preparation thereof, intermediates used in their preparation of, compositions containing them and the uses of such derivatives. The compounds of the present invention bind to the enzyme reverse transcriptase and are modulators, especially inhibitors thereof. As such, the compounds of the present invention are useful in the treatment of a variety of disorders including those in which the inhibition of reverse transcriptase is implicated. Disorders of interest include those caused by Human Immunodificiency Virus (HIV) and genetically related retroviruses, such as Acquired Immune Deficiency Syndrome (AIDS).