474-67-9

Basic information

• Product Name: BRASSICASTEROL
• Synonyms: (22E)-Ergosta-5,22-dien-3-ol;Brassicasterin;DELTA5,22-Ergostadien-3beta-ol;DELTA5,22-Ergostadienol;Ergosta-5,22-dien-3beta-ol;Ergosta-5,22-dien-3-ol, (3beta,22E)-;5, 22-CHOLESTADIEN-24BETA-METHYL-3BETA-OL;5,22-CHOLESTANDIEN-24B-METHYL-3B-OL
• CAS NO: 474-67-9
• Molecular Formula: C28H46O
• Molecular Weight: 398.66
• EINECS: 207-486-5
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Steroids
• Mol File: 474-67-9.mol
• Article Data: 14

Chemical Properties

• Melting Point: 205-213℃
• Boiling Point: 488.7°Cat760mmHg
• Flash Point: 213.4°C
• Appearance: /
• Density: 0.99g/cm³
• Storage Temp.: 2-8°C
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
• PKA: 15.03±0.70(Predicted)
• CAS DataBase Reference: BRASSICASTEROL(CAS DataBase Reference)
• NIST Chemistry Reference: BRASSICASTEROL(474-67-9)
• EPA Substance Registry System: BRASSICASTEROL(474-67-9)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 474-67-9(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 474-67-9 differently. You can refer to the following data:
1. A phytosterol found in canola oil, rapeseed oil, marine algae and shellfish. This compound has been shown to inhibit sterol Δ24-reductase, an enzyme involved in the mammalian cholesterol biosynthesis pathway.
2. Brassicasterol was used as standard to analyze the sterols from mussels sample by thin layer chromatography.

General Description

Brassicasterol is a plant sterol, sharing similar structure with cholesterol. It is obtained through the dietary sources, including sea food.

Biochem/physiol Actions

Brassicasterol is a plant sterol, structurally similar to cholesterol. Plant sterols compete with cholesterol and reduce the content of cholesterol incorporated into micelles thereby reducing its absorption. Brassicasterol reportedly decreases the progression of atherosclerosis. The level of brassicasterol in cerebrospinal fluid may be used as a prognostic factor for progression of Alzheimer′s disease.

Upstream product

• 57-87-4 Ergosterol 
• 5035-30-3 (3β,22E)-ergosta-5,7,22-trien-3-ol benzoate 
• 2458-53-9 brassicasterol acetate 
• 3037-46-5 (22E)-3α,5-cyclo-5α-ergosta-7,22-dien-6β-one 
• 81393-44-4 3β-methoxy-23,24-dinor-chol-5-en-22-al 
• 68702-73-8 (R)-(-)-(2,3-dimethylbutyl)triphenylphosphonium iodide 
• 88852-68-0 (22E)-6β-methoxy-3α,5-cyclo-24-β-methyl-5α-cholest-22-ene 
• 95307-27-0 O-methoxymethyl-ergosterol 
• 95307-26-9 3β-tert-Butyldimethylsilyloxy-ergosta-5,7,22-triene 
• 80779-42-6 (22E,24S)-3α,5-cyclo-5α-ergost-22-en-6β-ol 
• 81477-15-8 6β-methoxy-3α,5-cyclo-26,27-bisnor-5α-cholest-23-yn-22β-ol 
• 96615-21-3 (22E)-6β-methoxy-3α,5-cyclo-24-α-methyl-5α-cholest-22-en-26-oic acid ethyl ester 
• 81477-24-9 (22S,23Z)-6β-methoxy-26,27-bisnor-3α,5-cyclo-5α-cholest-23-en-22-ol 
• 2774-59-6 (22E)-3α,5-cyclo-5α-ergosta-7,22-dien-6β-ol 

Downstream Products

• 120663-52-7 3.5-dinitro-benzoic acid-(5α-ergostanyl-(3β)-ester) 
• 55515-03-2 3α-acetoxy-5β-ergost-22t-ene 
• 55515-02-1 3β-Acetoxy-5α-ergost-22-en 
• 18865-44-6 5β-ergost-22t-en-3-one 
• 55527-92-9 5β-ergosten-(22t)-ol-(3α) 
• 4356-09-6 campestanyl acetate 
• 91926-36-2 Toluene-4-sulfonic acid (3S,10R,13R,17R)-10,13-dimethyl-17-((E)-(1R,4R)-1,4,5-trimethyl-hex-2-enyl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester 
• 2458-53-9 Brassicasterol acetate 
• 91926-36-2 brassicasterol tosylate 
• 2638-60-0 3β-benzoyloxy-ergosta-5,22t-diene 
• 2458-53-9 brassicasterol acetate 

Relevant articles and documents

7-Dehydrocholesterol reductase activity is independent of cytochrome P450 reductase

7-Dehydrocholesterol reductase (DHCR7) catalyzes the final step in cholesterol synthesis. The enzyme utilizes NADPH as a source of electrons and has been reported to require NADPH-cytochrome P450 reductase (POR) as its redox partner. To test this hypothes

Process for recovery of plant sterols from by-product of vegetable oil refining

The process for recovery of plant sterols and tocopherols from deodorization distillates formed during chemical or physical refining of vegetable oils consists of the following steps: free fatty acids are removed from the deodorization distillate by vacuum distillation or by continuation solvent saponification, after the removal of free fatty acids, the received material is reacted with an aromatic carboxylic acid anhydride at a temperature of 50-150° C., under reduced pressure, after the treatment with anhydride, tocopherols are removed from the mixture, and crystalline free sterols are recovered from the distillation residue containing sterol esters, di- and triglycerides by transesterification.

A NEW SYNTHESIS OF BRASSICASTEROL

A new method has been developed for obtaining brassicasterol - the initial compound for the synthesis of the natural brassinosteroid epibrassinolide.