474-70-4

Basic information

• Product Name: Isopyrovitamine D2
• Synonyms: (9β,22E)-Ergosta-5,7,22-trien-3β-ol;Isopyrocalciferol;Isopyrovitamine D2
• CAS NO: 474-70-4
• Molecular Formula: C₂₈H₄₄O
• Molecular Weight: 396.64836
• Mol File: 474-70-4.mol
• Article Data: 3

Chemical Properties

• Melting Point: 112-115°
• Boiling Point: 501.5°C at 760 mmHg
• Flash Point: 216.3°C
• Appearance: /
• Density: 1g/cm³
• Vapor Pressure: 3.7E-12mmHg at 25°C
• Refractive Index: 1.542
• CAS DataBase Reference: Isopyrovitamine D2(CAS DataBase Reference)
• NIST Chemistry Reference: Isopyrovitamine D2(474-70-4)
• EPA Substance Registry System: Isopyrovitamine D2(474-70-4)

Safety Data

• Hazardous Substances Data: 474-70-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C28H44O/c1-18(2)19(3)7-8-20(4)24-11-12-25-23-10-9-21-17-22(29)13-15-27(21,5)26(23)14-16-28(24,25)6/h7-10,18-20,22,24-26,29H,11-17H2,1-6H3/b8-7+/t19-,20+,22-,24+,25-,26+,27-,28+/m0/s1

Upstream product

• 70005-45-7 ergosta-5,7,22-trien-3β-ol 
• 6411-40-1 3-acetoxy-3,5,7,22-ergosta-tetraene 
• 3946-26-7 (20S)-20-formyl-pregna-4,6-dien-3-one 
• 3986-89-8 (20S)-3-oxopregn-4-ene-20-carboxaldehyde 
• 40736-33-2 (20S)-20-hydroxymethylpregn-4-en-3-one 
• 1108-03-8 ergosta-5,7,22-trien-3β-yl acetate 
• 81139-11-9 C₃₈H₅₂N₂O₃ 
• 81139-13-1 C₃₆H₄₈N₂O₃ 
• 81126-48-9 C₃₆H₅₀N₂O₂ 
• 81126-47-8 C₄₃H₅₄N₂O₃ 
• 41238-09-9 C₃₈H₅₀N₂O₄ 

Downstream Products

• 705926-28-9 (22E)-3β-hydroxyergosta-8(14),22-dien-15-one 
• 55401-50-8 (3S,5S,8R,9S,10S,13R,17R)-17-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-10,13-dimethyl-2,3,4,5,6,7,8,9,10,11,12,13,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate 
• 1449-60-1 (10S)-3c-Acetoxy-10r.13c-dimethyl-17c-((1R:4R)-1.4.5-trimethyl-hexen-(2t)-yl)-(5ξH.9cH.14tH)-Δ⁷-tetradecahydro-1H-cyclopenta[a]phenanthren 
• 474-59-9 (10S)-3c-Hydroxy-10r.13c-dimethyl-17c-((1R:4S)-1.4.5-trimethyl-hexyl)-(5ξH.8ξH.9cH.14tH)-hexadecahydro-1H-cyclopenta[a]phenanthren 
• 1449-60-1 Acetic acid (3S,5S,9R,10S,13R,17R)-10,13-dimethyl-17-((E)-(1R,4R)-1,4,5-trimethyl-hex-2-enyl)-2,3,4,5,6,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester 
• 5984-78-1 O-(3.5-dinitro-benzoyl)-isopyroergocalciferol 

Relevant articles and documents

Methods for preparing cholesterol, and derivatives and analogs thereof

The present invention relates to the field of pharmaceutical chemistry, and in particular to methods of preparing cholesterol,and derivatives and analogs thereof. The cholesterol derivatives include, but not limited to, 7-dehydrocholesterol, 25-hydroxycholesterol, 25- hydroxy7dehydrocholesterol and ergosterol. In the invention, phytosterol can be used as a raw material to prepare the compound shown in the formula I through microbial conversion, and then cholesterol and the derivatives and analogues thereof are prepared.

PRODUCTION AND PROPERTIES OF 1,4-CYCLIC ADDUCTS OF STEROID 5,7-DIENES WITH 3,6-PYRIDAZINEDIONE AND 1,4-PHTHALAZINEDIONE

1,3-Phthalazinedione and 3,6-pyridazinedione, obtained by the action of lead tetraacetate or manganese dioxide on phthalohydrazide and of lead tetraacetate on malehydrazide, form 1,4-cyclic adducts in reaction with steroid 5,7-dienes; the reaction is promoted by the presence of aliphatic alcohols.The initial dienes can be regenerated from the synthesized cyclic adducts by reductive cleavage with complex metal hydrides or by electrochemical reduction.In addition to ergosterol, the action of a water-alcohol solution of alkali on the cyclic adduct of ergosterol with 1,4-phthalazinedione gives a salt-like compound, which is converted into 9(11)-dehydroergosterol and phthalohydrazide by the action of acids.