4740-77-6Relevant articles and documents
1,3-butanediol synthesis method and system
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Paragraph 0096; 0098; 0102; 0106; 0108; 0110; 0112; 0114, (2018/09/08)
The invention discloses a 1,3-butanediol synthesis method and system. For the synthesis method, 1,3-butanediol is produced from acetaldehyde by a 2,6-dimethyl-1,3-dioxane-4-alcohol route; the stability of the intermediate product is improved; the selectivity of the 1,3-butanediol is improved; the generation of harmful, easy-color-developing and smelly crotonaldehyde and derivatives is reduced. Meanwhile, a tubular reactor with a built-in component is used as a condensation reactor; the heat can be effectively removed; the low-temperature cooling load is reduced; the reaction controllability isimproved; the unnecessary backmixing is reduced; the generation of by-products is reduced. The 2,6-dimethyl-1,3-dioxane-4-alcohol pyrolysis is performed in a mode of firstly performing low-temperature flash evaporation and then performing catalytic reaction distillation; the acetaldehyde is recovered; the raw material utilization rate is effectively improved; the yield of the final product is improved; the chromaticity and the odor can meet the requirements of most high-level application.
One-Pot Synthesis of (S)-Baclofen via Aldol Condensation of Acetaldehyde with Diphenylprolinol Silyl Ether Mediated Asymmetric Michael Reaction as a Key Step
Hayashi, Yujiro,Sakamoto, Daisuke,Okamura, Daichi
supporting information, p. 4 - 7 (2016/01/15)
An efficient asymmetric total synthesis of (S)-baclofen was accomplished via a one-pot operation from commercially available materials using sequential reactions, such as aldol condensation of acetaldehyde, diphenylprolinol silyl ether mediated asymmetric Michael reaction of nitromethane, Kraus-Pinnick oxidation, and Raney Ni reduction. Highly enantioenriched baclofen was obtained in one pot with a good yield over four reactions.
