474086-68-5

Upstream product

• 67-56-1 methanol 
• 474086-12-9 (3R,4S,5S)-2-Benzyl-3-[(2S,3R)-3-methoxy-1-(4-methoxy-phenyl)-4-oxo-azetidin-2-yl]-isoxazolidine-4,5-dicarboxylic acid dimethyl ester 
• 29601-98-7 N-benzylhydroxylamine hydrochloride 
• 474086-03-8 C₁₉H₂₀N₂O₄ 
• 180062-99-1 3-methoxy-1-(4-methoxy-phenyl)-4-oxo-azetidine-2-carbaldehyde 

Relevant academic research and scientific papers

Efficient entry to highly functionalized β-lactams by regio- and stereoselective 1,3-dipolar cycloaddition reaction of 2-azetidinone-tethered nitrones. Synthetic applications

Racemic as well as optically pure 2-azetidinone-tethered nitrones, both cyclic and acyclic, were smoothly prepared from 4-oxoazetidine-2-carbaldehydes. The regio- and diastereoselectivities of the intermolecular 1,3-dipolar cycloaddition reactions of 2-azetidinone-tethered nitrones with substituted alkenes and alkynes were investigated. 2-Azetidinone-tethered nitrones on reacting with various dipolarophiles yielded isoxazolinyl-, isoxazolidinyl-, or fused polycyclic-β-lactams, exhibiting good regio- and facial stereoselectivity in the most of the cases. In addition, some interesting transformations of these cycloadducts were performed, yielding aziridinyl β-lactams or functionalized β-alkoxycarbonyl γ-lactams (derivatives of the aza analogue of paraconic acid).