474125-09-2

Basic information

• Product Name: 8-Methoxy-2-trifluoromethylquinolin-4-one
• CAS NO: 474125-09-2
• Molecular Weight: 243.185
• Mol File: 474125-09-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 8-Methoxy-2-trifluoromethylquinolin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Methoxy-2-trifluoromethylquinolin-4-one(474125-09-2)
• EPA Substance Registry System: 8-Methoxy-2-trifluoromethylquinolin-4-one(474125-09-2)

Safety Data

• Hazardous Substances Data: 474125-09-2(Hazardous Substances Data)

Upstream product

• 371-26-6 ethyl 4,4,4-trifluorobutanoate 
• 90-04-0 2-methoxy-phenylamine 
• 372-31-6 ethyl 4,4,4-trifluoroacetoacetate 

Downstream Products

• 199872-29-2 8-Methoxy-2-(trifluoromethyl)quinoline-5-carboxylic acid 
• 41192-89-6 4-chloro-8-methoxy-2-trifluoromethyl-quinoline 

Relevant articles and documents

8-Methoxyquinolines as PDE4 inhibitors.

The synthesis and pharmacological profile of a novel series of 2-substituted 8-methoxyquinolines is described. The 2-trifluoromethyl compound was found to be a potent inhibitor of phosphodiesterase type 4 (PDE4).

PYRAZOLONE DERIVATIVE AND PDE INHIBITOR CONTAINING THE SAME AS ACTIVE INGREDIENT

It is to provide a novel pyrazolone derivative represented by the following general formula (1), which is useful as a pharmaceutical and has a phosphodiesterase inhibitory action: wherein R1,R2: C1-6 alkyl; R3,R4: H, X, C1-6 alkoxy; Z:O, S; A:AA, BB, wherein AA represents wherein BB represents wherein R5: H, C1-6 alkyl ; R6,R7: C1-6 alkyl.