474266-27-8

Basic information

• Product Name: 1,8-Naphthyridine, 2-chloro-3-(4-methoxyphenyl)-
• CAS NO: 474266-27-8
• Molecular Formula: C15H11ClN2O
• Molecular Weight: 270.718
• Mol File: 474266-27-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1,8-Naphthyridine, 2-chloro-3-(4-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,8-Naphthyridine, 2-chloro-3-(4-methoxyphenyl)-(474266-27-8)
• EPA Substance Registry System: 1,8-Naphthyridine, 2-chloro-3-(4-methoxyphenyl)-(474266-27-8)

Safety Data

• Hazardous Substances Data: 474266-27-8(Hazardous Substances Data)

Upstream product

• 60467-64-3 2-amino-3-(p-methoxyphenyl)-1,8-naphthyridine 
• 104-47-2 p-methoxybenzylnitrile 
• 7521-41-7 2-Aminonicotinaldehyde 
• 477849-11-9 1,2-dihydro-3-(4-methoxyphenyl)-1,8-naphthyridin-2(1H)-one 

Downstream Products

• 519040-77-8 2-(4-acetylphenylamino)-3-(4-methoxyphenyl)-1,8-naphthyridine 
• 1075254-06-6 C₂₁H₁₄N₄O₂ 
• 477849-20-0 N-[1-(3,4-Dimethoxy-phenyl)-meth-(Z)-ylidene]-N'-[3-(4-methoxy-phenyl)-[1,8]naphthyridin-2-yl]-hydrazine 
• 477849-19-7 N-benzo[1,3]dioxol-5-ylmethylene-N'-[3-(4-methoxy-phenyl)-[1,8]naphthyridin-2-yl]-hydrazine 

Relevant articles and documents

A Simple “Green” Synthesis of Novel Bis(3-aryl-1,8-naphthyridin-2-yl)sulfanes and 2-(Methylthio)-3-aryl-1,8-naphthyridines under Microwave Irradiation and Conventional Conditions

An eco-friendly and highly efficient synthesis of substituted bis(3-aryl-1,8-naphthyridin-2-yl)-sulfanes and 2-(methylthio)-3-aryl-1,8-naphthyridines under microwave and conventional conditions. The products are obtained with high yields and purity within short reaction time. The synthesized derivatives are screened for anti-microbial activity against bacteria and fungi. Molecular docking of the synthesized compounds with DNA Gyrase is studied.

An Efficient Microwave-Assisted Synthesis of Novel 2-{4-[(3-Aryl-1,8-naphthyridin-2-yl)amino]phenyl}-1H-benzo[de]isoquinoline-1,3(2H)-diones and Their Antimicrobial Activity

The Buchwald–Hartwig amination reaction between 2-chloro-3-aryl-1,8-naphthyridines and 2-(4-aminophenyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione in the presence of the catalytic system Pd(PPh3)4 and the base KO-t-Bu in toluene was studied. The reaction was initiated by microwave irradiation. Highly efficient synthesis has been developed for 2-{4-[(3-aryl-1,8-naphthyridin-2-yl)amino]phenyl}-1H-benzo[de]isoquinoline-1,3(2H)-diones. Structures of the synthesized compounds were evaluated by IR, 1H and 13C NMR spectroscopy. All products were tested for antimicrobial activity against Escheria coli, Bacillus subtilis, Klebsiella pneumoniae, and Staphylococcus aureus.