474274-56-1

Upstream product

• 542-69-8 1-iodo-butane 
• 91955-16-7 4-((4-(hydroxymethyl)phenyl)diazenyl)phenol 
• 109-65-9 1-bromo-butane 

Downstream Products

• 474274-58-3 (4-bromomethyl-phenyl)-(4-butoxy-phenyl)-diazene 
• 474274-61-8 C₄₁H₄₃BrN₄O₄ 
• 474274-59-4 {3,5-bis-[4-(4-butoxy-phenylazo)-benzyloxy]-phenyl}-methanol 
• 474274-60-7 C₄₁H₄₃N₇O₄ 

Relevant academic research and scientific papers

Development of photoswitchable estrogen receptor ligands

Photopharmacology has attracted attention as an approach for the development of novel therapeutics because it allows regulation of the bioactivity of compounds based on their conformational change by photo-irradiation. Previously, we have reported several types of selective estrogen receptor (ER) modulators based on diphenylmethane skeleton. To develop novel photopharmacological reagents, we designed and synthesized a set of ER ligands based on azobenzene skeleton, which can switch its conformation following UV irradiation. Our results showed that after UV irradiation, the Z-form of the synthesized compound 9 interacted with ERα, with a KD value of 2.5μM, whereas the E-form of compound 9 did not bind ability to ERα at 10μM.

Containing azobenzene group of the method for preparation of alcohol (by machine translation)

The invention relates to a preparation method of organic compound, and in particular relates to a containing azobenzene group of the ester (or acid) containing azobenzene group reduced to alcohol of preparation method. This invention adopts the containing azobenzene group of the ester (or acid) as a reaction substrate, the reaction solvent, the borohydride + Lewis acid as a complex reducing agent, reflux and the reduction reaction, after extraction, washing, and steaming and, by recrystallization to obtain a product. The present invention production process is simple, low cost, high yield, environment-friendly process, without the need for conventional of a reducing agent such as lithium aluminum hydride can be completed. The reduction system of the present invention containing azobenzene ester (acid) with specificity, hydroboron or Lewis acid type, are unable to complete the reaction. (by machine translation)

Dendritic fullerenes (C60) with photoresponsive azobenzene groups

Fullerene-cored dendrimers bearing up to eight photoisomerizable azobenzene groups in the periphery have been synthesized as potential photoswitches and spectroscopically characterized.