91955-16-7Relevant academic research and scientific papers
Hypoxia-Activated PEGylated Conditional Aptamer/Antibody for Cancer Imaging with Improved Specificity
Zhou, Fang,Fu, Ting,Huang, Qin,Kuai, Hailan,Mo, Liuting,Liu, Honglin,Wang, Qianqian,Peng, Yongbo,Han, Dongmei,Zhao, Zilong,Fang, Xiaohong,Tan, Weihong
, p. 18421 - 18427 (2019)
Aptamers and antibodies, as molecular recognition probes, play critical roles in cancer diagnosis and therapy. However, their recognition ability is based on target overexpression in disease cells, not target exclusivity, which can cause on-target off-tumor effects. To address the limitation, we herein report a novel strategy to develop a conditional aptamer conjugate which recognizes its cell surface target, but only after selective activation, as determined by characteristics of the disease microenvironment, which, in our model, involve tumor hypoxia. This conditional aptamer is the result of conjugating the aptamer with PEG5000-azobenzene-NHS, which is responsive to hypoxia, here acting as a caging moiety of conditional recognition. More specifically, the caging moiety is unresponsive in the intact conjugate and prevents target recognition. However, in the presence of sodium dithionite or hypoxia (2) or in the tumor microenvironment, the caging moiety responds by allowing conditional recognition of the cell-surface target, thereby reducing the chance of on-target off-tumor effects. It is also confirmed that the strategy can be used for developing a conditional antibody. Therefore, this study demonstrates an efficient strategy by which to develop aptamer/antibody-based diagnostic probes and therapeutic drugs for cancers with a unique hypoxic microenvironment.
Red light-triggered photoreduction on a nucleic acid template
Deussner-Helfmann, Nina,Duchstein, Patrick,Dutta, Subrata,Heilemann, Mike,Kn?r, Günther,Mokhir, Andriy,Rühle, Jennifer,Schikora, Margot,Zahn, Dirk,Zatsepin, Timofei
supporting information, p. 10026 - 10029 (2020/09/23)
Conjugate Sn(iv)(pyropheophorbide a)dichloride-(peptide nucleic acid) catalyzes reduction of azobenzene derivatives in the presence of complementary nucleic acid (NA) upon irridiation with red light (660 nm). This is the first red light-induced NA-templat
Hypoxia-Induced Pro-Protein Therapy Assisted by a Self-Catalyzed Nanozymogen
Li, Xudong,Wei, Yuansong,Wu, Yuchen,Yin, Lichen
supporting information, p. 22544 - 22553 (2020/10/12)
The success of intracellular protein therapy demands efficient delivery and selective protein activity in diseased cells. Therefore, a cascaded nanozymogen consisting of a hypoxia-activatable pro-protein, a hypoxia-inducing protein, and a hypoxia-strengthened intracellular protein delivery nanovehicle was developed. RPAB, an enzymatically inactive pro-protein of RNase, reversibly caged with hypoxia-cleavable azobenzene, was delivered with glucose oxidase (GOx) using hypoxia-responsive nanocomplexes (NCs) consisting of azobenzene-cross-linked oligoethylenimine (AOEI) and hyaluronic acid (HA). Upon NC-mediated delivery into cancer cells, GOx catalyzed glucose decomposition and aggravated tumoral hypoxia, which drove the recovery of RPAB back to the hydrolytically active RNase and expedited the degradation of AOEI to release more protein cargoes. Thus, the catalytic reaction of the nanozymogen was self-accelerated and self-cycled, ultimately leading to a cooperative anti-cancer effect between GOx-mediated starvation therapy and RNase-mediated pro-apoptotic therapy.
Light and reduction responsive supra-amphiphile for controllable fluorescence based on Pillar[6]arene
Wu, Yitao,Shangguan, Liqing,Liu, Peiren,Liu, Yuezhou,Li, Qi,Cao, Jiajun,Zhu, Huangtianzhi
, (2020/09/18)
As increasing demands of smart fluorescent materials, developing new systems with controllable emissions is more essential. Here we report a pillar[6]arene and tetraphenylethene (TPE)-based supra-amphiphile, which shows dual-responsiveness and tunable emi
Worm-like micelles can be formed of the light response type quaternary ammonium salt cationic surfactant and its synthetic method
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Paragraph 0037; 0040; 0041, (2019/01/08)
The invention discloses a photo-responsive quaternary cationic surfactant capable of forming a wormlike micelle and a synthetic method thereof. The surfactant has a structural formula as shown in the specification. In the formula, R represents a straight-
Targeted dendrimer-drug conjugates
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Page/Page column 45, (2016/06/13)
The invention provides for dendrimer conjugates useful for liver-specific delivery of therapeutic agents. The therapeutic agent is associated to the dendrimer through a enzyme-cleavable covalent linkage.
