474302-74-4Relevant articles and documents
Conformational analysis of the cis- and trans-adducts of the Pictet-Spengler reaction. Evidence for the structural basis for the C(1)-N(2) scission process in the cis- to trans-isomerization
Han, Dongmei,Foersterling, F. Holger,Deschamps, Jeffrey R.,Parrish, Damon,Liu, Xiaoxiang,Yin, Wenyuan,Huang, Shengming,Cook, James M.
, p. 75 - 82 (2008/03/31)
The stable conformations of both the trans- and cis-1,3-disubstituted Nb-benzyl stereoisomers of the Pictet-Spengler reaction have been determined by NMR spectroscopy and X-ray crystallography in order to better understand the C(1)-N(2) cis- to
A general strategy for the synthesis of vincamajine-related indole alkaloids: Stereocontrolled total synthesis of (+)-dehydrovoachalotine, (-)-vincamajinine, and (-)-11-methoxy-17-epivincamajine as well as the related quebrachidine diol, vincamajine diol,
Yu, Jianming,Wearing, Xiangyu Z.,Cook, James M.
, p. 3963 - 3979 (2007/10/03)
The highly convergent stereocontrolled total synthesis of (-)-vincamajinine (7), (-)-11-methoxy-17-epivincamajine (9), and the oxygen-bridged (+)-dehydrovoachalotine (22) are described. Key steps in the synthesis of 7 and 9 involved the stereospecific eno
Regiospecific, enantiospecific total synthesis of the alkoxy-substituted indole bases, 16-epi-Na-methylgardneral, 11-methoxyaffinisine, and 11-methoxymacroline as well as the indole alkaloids alstophylline and macralstonine
Liu, Xiaoxiang,Deschamp, Jeffrey R.,Cook, James M.
, p. 3339 - 3342 (2007/10/03)
(matrix presented) A regiospecific, enantiospecific approach to the synthesis of ring-A-substituted indole alkaloids was developed via a doubly convergent strategy. The asymmetric Pictet-Spengler reaction and enolate-driven palladium cross-coupling proces