474335-73-4Relevant academic research and scientific papers
Copper-catalyzed tandem reaction between imines and alcohols leading to indoles
Kamijo, Shin,Sasaki, Yuya,Yamamoto, Yoshinori
, p. 35 - 38 (2007/10/03)
A copper-catalyzed tandem reaction between 2-alkynyl-N-arylideneanilines and alcohols is found to produce N-(alkoxybenzyl)indoles in good to high yields. A wide variety of substituted N-(alkoxybenzyl)indole derivatives can be synthesized by utilizing this
A facile method for the synthesis of polycyclic indole derivatives: The generation and reaction of tungsten-containing azomethine ylides
Kusama, Hiroyuki,Takaya, Jun,Iwasawa, Nobuharu
, p. 11592 - 11593 (2007/10/03)
Treatment of N-(o-alkynylphenyl)imine derivatives with W(CO)5(L) induces the 5-endo-mode of cyclization of the imine nitrogen onto the electrophilically activated alkyne moiety to afford a novel reactive species, a metal-containing azomethine ylide. [3 + 2] cycloaddition of this ylide species with various electron-rich alkenes proceeds smoothly to give unstable carbene complexes, which in turn undergo 1,2-hydrogen-, alkyl-, and aryl-migration to afford in good yield 6-5-5 tricyclic indole skeletons having an alkyl or an aryl substituent at the 3-position of the indole nucleus. Copyright
