47459-90-5

Upstream product

• 100398-76-3 N,N-bis-(4-chloro-phenyl)-thiourea 
• 106-47-8 4-chloro-aniline 
• 100958-87-0 Trichlormethansulfonsaeure-<4-chlor-anilid> 
• 291-21-4 [1,3,5]trithiane 
• 7392-67-8 1-(4-chlorophenyl)-3-phenylthiourea 
• 31641-65-3 N-p-chlorophenyltriphenylphosphinimine 
• 1220-00-4 1,3-bis(4-chlorophenyl)thiourea 
• 7553-56-2 iodine 

Downstream Products

• 860196-87-8 (4-chloro-phenyl)-(6-chloro-2-phenyl-[4]quinolyl)-amine 
• 2131-55-7 4-Chlorophenyl isothiocyanate 

Relevant academic research and scientific papers

Ionic and Neutral Half-Sandwich Guanidinatoruthenium(II) Complexes and Their Solution Behavior

Ionic and neutral half-sandwich guanidinatoruthenium(II) complexes [(η6-C10H14)RuL(κ2(N,N′){(ArN)2C-N(H)Ar})][OTf] [Ar = 4-MeC6H4, L = 2-methylimidazole (1); Ar = 2-MeC6H4, L = 1,3,5-triaza-7-phosphaadamantane (PTA; 2)], [(ArNH)3C][(η6-C10H14)RuCl3] [Ar = 2-ClC6H4 (3)] and [(η6-C10H14)RuCl(κ2(N,N′){(ArN)2C-N(H)Ar})] [Ar = 2-ClC6H4 (4), 2-FC6H4 (5), 4-ClC6H4 (6), and 4-(NO2)C6H4 (7)] have been isolated and the molecular structures of all but 6 were determined by single-crystal X-ray diffraction. VT 31P{1H} NMR spectroscopy of complex 2 revealed the presence of a mixture of four isomers in a ratio of appproximately 1.4:11.0:1.6:0.1. Theoretical calculations were performed on the syn-syn, syn-anti, anti-syn, and anti-anti conformers of 2, which revealed syn-anti to be the most stable conformer, both in the gas phase and in solution. Furthermore, the energies relating to the interactions between the lone pairs of the nitrogen atoms of the CN3 unit and the antibonding orbital of the central carbon atom in the syn-anti conformer of 2 were investigated by NBO analysis. The 1H NMR spectrum of 3 reveals the presence of two species and their ratio is dependent upon the concentration of 3 in CDCl3 and on the amount of D2O in CD3CN. The two species have been ascribed to the presence of a monomer and a water-bridged dimer. The new complexes 1-7 were screened as pre-catalysts in the transfer hydrogenation of acetophenone and complex 3 was tested as a pre-catalyst in the transfer hydrogenation of a variety of ketones to explore the scope of the reaction.

Novel Desulphurization of Thiourea Derivatives by Alkaline Autoxidation

Autoxidation of 1,3-disubstituted thioureas in the presence of oxygen and tertiary butoxide in tertiary butanol afforded the corresponding ureas in good yields together with small amounts of the corresponding guanidines while the same treatment of benz- or naphth-imidazole-2-thiones gave the parent imidazoles and the 2-sulphonic acids.

Novel Desulphurization of 1,3-Disubstituted Thioureas by Superoxide Anion (O2*-): One-step Synthesis of 1,2,3-Trisubstituted Guanidines from 1,3-Disubstituted Thioureas

Treatment of 1,3-diarylthioureas with superoxide anion (O2*-) at 20 deg C in tetrahydrofuran or acetonitrile resulted in the formation of 1,2,3-triarylguanidines in excellent yields.