474645-90-4

Upstream product

• 402-43-7 p-trifluoromethylphenyl bromide 
• 131347-76-7 (R)-β-aminopentanoic acid 
• 80914-37-0 (R)-β-aminopentanoic acid hydrochloride 
• 142342-74-3 (R)-3-amino-valeric acid ethyl ester 
• 1027896-34-9 (R)-4-ethyl-1-[4-(trifluoromethyl)phenyl]-2-azetidinone 

Downstream Products

• 667937-05-5 (3R)-3-(4-trifluoromethylphenylamino)pentanoic acid amide 

Relevant academic research and scientific papers

A PROCESS FOR PREPARING TETRAHYDROQUINOLINE DERIVATIVES

The present invention is to provide a process for preparing optically active tetrahydroquinoline derivatives which can be used for the treatment and/or prevention of diseases such as arteriosclerotic diseases, dyslipidemia and the like, and a process for preparing synthetic intermediates thereof. Specifically, (2R,4S)-2-ethyl-6-trifluoromethyl-1,2,3,4-tetrahydroquinolin-4-ylamine or a salt thereof is prepared with fewer steps without using an optical resolution, and the optically active tetrahydroquinoline derivatives are obtained from the amine compound.

Method for producing (R) -3- [4- (trifluoromethyl) phenylamino] -pentanoic acid amide derivative

The present invention provides a method for easily producing an (R)-3-[4-(trifluoromethyl)phenylamino]-pentanoic acid amide derivative useful for an intermediate for pharmaceutical products, particularly an inhibitor of a cholesteryl ester transfer protei