474645-93-7

Upstream product

• 95-14-7 1,2,3-Benzotriazole 
• 343798-02-7 (1-benzotriazol-1-yl-propyl)-(4-trifluoromethyl-phenyl)-amine 
• 15204-93-0 methyl ethenylcarbamate 
• 667937-05-5 (3R)-3-(4-trifluoromethylphenylamino)pentanoic acid amide 
• 474645-91-5 (R)-3-((4-(trifluoromethyl)phenyl)amino)pentanenitrile 
• 474645-97-1 (R)-3-aminopentanenitrile methanesulfonic acid salt 
• 198493-28-6 (R)-N-tert-butyloxycarbonyl-3-aminopentanenitrile 
• 400090-60-0 (R)-3-aminopentanenitrile 
• 455-14-1 4-trifluoromethylphenylamine 
• 948847-52-7 (E)-pent-2-enoyl-carbamic acid methyl ester 
• 474645-92-6 (3R)-[3-(4-trifluoromethylphenylamino)pentanoyl]carbamic acid methyl ester 

Downstream Products

• 262352-17-0 torcetrapib 

Relevant academic research and scientific papers

A concise asymmetric synthesis of torcetrapib

(Chemical Equation Presented) Optically active torcetrapib was synthesized in seven steps from achiral precursors without the need for protecting groups, utilizing an enantioselective aza-Michael reaction to achieve asymmetry.

Asymmetric synthesis of the cholesteryl ester transfer protein inhibitor torcetrapib

Previously our group reported synthetic efforts used to synthesize kilogram quantities of the cholesteryl ester transfer protein (CETP) inhibitor torcetrapib, 1, via a mid-stage resolution. This account describes research conducted to develop an asymmetri

METHOD FOR PRODUCING OPTICALLY ACTIVE AMINES

The present invention provides a method for producing optically active amines of formula (9) or (10): which comprises reacting an imine equivalent of formula (6): with an alkene of formula (7) or an alkyne of formula (8): in the presence of a chiral catal

METHOD FOR PRODUCING AN OPTICALLY ACTIVE TETRAHYDROQUINOLINE

The present invention provides an industrially advantageous production method of optically active tetrahydroquinolines of formula (1), which comprises: 1) a step of reacting a β-ketoester of formula (2) with an amine of formula (3) to produce an enaminoester of formula (4); 2) a step of subjecting the enaminoester of formula (4) above obtained in 1) to asymmetric hydrogenation to produce an optically active β-amino acid derivative of formula (5); 3) a step of amidating the optically active β-amino acid derivative (5) above obtained in 2) to produce an amide of formula (6); 4) step of alkoxycarbonylating the amide of formula (6) above obtained in 3) to produce a compound of formula (7); and 5) a step of subjecting the compound of formula (7) above to cyclization to produce the optically active tetrahydroquinoline of formula (1).