474645-93-7

Basic information

• Product Name: METHYL [2-ETHYL-6-(TRIFLUOROMETHYL)-1,2,3,4-TETRAHYDROQUINOLIN-4-YL]CARBAMATE
• Synonyms: METHYL [2-ETHYL-6-(TRIFLUOROMETHYL)-1,2,3,4-TETRAHYDROQUINOLIN-4-YL]CARBAMATE
• CAS NO: 474645-93-7
• Molecular Formula: C₁₄H₁₇F₃N₂O₂
• Molecular Weight: 302.29
• Mol File: 474645-93-7.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: METHYL [2-ETHYL-6-(TRIFLUOROMETHYL)-1,2,3,4-TETRAHYDROQUINOLIN-4-YL]CARBAMATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL [2-ETHYL-6-(TRIFLUOROMETHYL)-1,2,3,4-TETRAHYDROQUINOLIN-4-YL]CARBAMATE(474645-93-7)
• EPA Substance Registry System: METHYL [2-ETHYL-6-(TRIFLUOROMETHYL)-1,2,3,4-TETRAHYDROQUINOLIN-4-YL]CARBAMATE(474645-93-7)

Safety Data

• Hazardous Substances Data: 474645-93-7(Hazardous Substances Data)

Upstream product

• 474645-92-6 (3R)-[3-(4-trifluoromethylphenylamino)pentanoyl]carbamic acid methyl ester 
• 95-14-7 1,2,3-Benzotriazole 
• 343798-02-7 (1-benzotriazol-1-yl-propyl)-(4-trifluoromethyl-phenyl)-amine 
• 15204-93-0 methyl ethenylcarbamate 
• 667937-05-5 (3R)-3-(4-trifluoromethylphenylamino)pentanoic acid amide 
• 474645-91-5 (R)-3-((4-(trifluoromethyl)phenyl)amino)pentanenitrile 
• 474645-97-1 (R)-3-aminopentanenitrile methanesulfonic acid salt 
• 198493-28-6 (R)-N-tert-butyloxycarbonyl-3-aminopentanenitrile 
• 400090-60-0 (R)-3-aminopentanenitrile 
• 455-14-1 4-trifluoromethylphenylamine 
• 948847-52-7 (E)-pent-2-enoyl-carbamic acid methyl ester 

Downstream Products

• 262352-17-0 torcetrapib 

Relevant articles and documents

A concise asymmetric synthesis of torcetrapib

(Chemical Equation Presented) Optically active torcetrapib was synthesized in seven steps from achiral precursors without the need for protecting groups, utilizing an enantioselective aza-Michael reaction to achieve asymmetry.

METHOD FOR PRODUCING OPTICALLY ACTIVE AMINES

The present invention provides a method for producing optically active amines of formula (9) or (10): which comprises reacting an imine equivalent of formula (6): with an alkene of formula (7) or an alkyne of formula (8): in the presence of a chiral catal