474713-41-2Relevant academic research and scientific papers
Small molecule microarray-facilitated screening of affinity-based probes (AfBPs) for γ-secretase
Shi, Haibin,Liu, Kai,Xu, Ashley,Yao, Shao Q.
supporting information; experimental part, p. 5030 - 5032 (2010/01/06)
A small molecule microarray (SMM) platform is developed herein, which enables high-throughput discovery of affinity-based probes (AfBPs) against γ-secretase.
Efficient method to prepare hydroxyethylamine-based aspartyl protease inhibitors with diverse P1 side chains
Chino, Masao,Wakao, Masahiro,Ellman, Jonathan A
, p. 6305 - 6310 (2007/10/03)
An efficient procedure for the solid-phase synthesis of hydroxyethylamine-based aspartyl protease inhibitors is described. The 1,2-bromo alcohol 4 is the key intermediate and is prepared in four-steps in good overall yield from commercial available amino acids.
