474924-87-3

Upstream product

• 614-27-7 methyl 3-oxo-3-phenylpropionate 
• 474924-68-0 (4-methoxy-phenyl)-(5-nitro-3-phenyl-pent-1-enyl)-carbamic acid tert-butyl ester 
• 1026978-20-0 (S)-5-Nitro-3-phenyl-pentanoic acid 
• 474925-60-5 5-nitro-3-phenyl-pentanoic acid methyl ester 

Downstream Products

• 474925-46-7 1-benzyl-3-hydroxy-4-phenyl-piperidine 
• 474925-47-8 1-benzyl-2-oxo-4-phenyl-piperidine-3-carboxylic acid methyl ester 
• 474925-50-3 1,3-dibenzyl-4-phenylpiperidin-2-one 
• 474924-98-6 (S)-N-benzyl-4-phenyl-2-piperidinone 

Relevant academic research and scientific papers

Synthesis of chiral lactams: Via asymmetric hydrogenation of α,β-unsaturated nitriles

A highly efficient Rh-catalyzed enantioselective hydrogenation of α,β-unsaturated nitriles containing ester/amide groups has been developed. Under mild conditions, with a complex of rhodium and (S,S)-f-spiroPhos as the catalyst, a variety of α,β-unsaturated nitriles bearing an ester or amide group were successfully hydrogenated to the corresponding chiral nitriles with excellent enantioselectivities (up to 99.7% ee) and high turnover numbers (TON = 10000). Furthermore, this catalyst system was also successfully applied to the synthesis of important chiral pharmacophore fragments, lactams, Paroxetine and amino acids.

Asymmetric carbon-carbon bond formations in conjugate additions of lithiated N-Boc allylic and benzylic amines to nitroalkenes: Enantioselective synthesis of substituted piperidines, pyrrolidines, and pyrimidinones

(-)-Sparteine mediated lithiations of N-Boc-allylic and benzylic amines provide configurationally stable intermediates which on conjugate additions to nitroalkenes provide highly enantioenriched enecarbamate products in good yields, and with high diastere