474925-47-8

Upstream product

• 100-39-0 benzyl bromide 
• 1026978-20-0 (S)-5-Nitro-3-phenyl-pentanoic acid 
• 474925-60-5 5-nitro-3-phenyl-pentanoic acid methyl ester 
• 35274-92-1 3-(benzylamino)-1-phenylpropan-1-one hydrochloride 
• 100-46-9 benzylamine 
• 98-86-2 acetophenone 
• 79-22-1 methyl chloroformate 
• 474924-98-6 (S)-N-benzyl-4-phenyl-2-piperidinone 
• 474924-68-0 (4-methoxy-phenyl)-(5-nitro-3-phenyl-pent-1-enyl)-carbamic acid tert-butyl ester 
• 474924-87-3 (S)-4-phenylpiperidin-2-one 

Relevant academic research and scientific papers

Catalytic Asymmetric Hydrogenation of Tetrasubstituted Unsaturated Lactams: An Efficient Approach to Enantioenriched 3,4-Disubstituted Piperidines

Asymmetric hydrogenation of tetrasubstituted alkenes remains a formidable challenge in asymmetric catalysis. We report herein an unprecedented Rh-catalyzed enantioselective and diastereoselective hydrogenation of easily accessed α,β-disubstituted unsaturated lactams to afford synthetically valuable chiral lactams with 1,2-consecutive stereocenters. The reaction could be performed on the gram scale, and the products could be concisely transformed to enantiomerically pure trans-3,4-disubstituted piperidines, which are prevalent structural units in medicinal agents.

Asymmetric carbon-carbon bond formations in conjugate additions of lithiated N-Boc allylic and benzylic amines to nitroalkenes: Enantioselective synthesis of substituted piperidines, pyrrolidines, and pyrimidinones

(-)-Sparteine mediated lithiations of N-Boc-allylic and benzylic amines provide configurationally stable intermediates which on conjugate additions to nitroalkenes provide highly enantioenriched enecarbamate products in good yields, and with high diastere