474973-44-9

Upstream product

• 1254691-84-3 ethyl 2-phenoxypyridine-3-carboxylate 
• 35620-71-4 2-phenoxypyridine-3-carboxylic acid 
• 108-95-2 phenol 
• 2942-59-8 2-chloronicotinic acid 
• 872-85-5 pyridine-4-carbaldehyde 
• 175135-01-0 2-phenoxynicotinic acid hydrazide 

Relevant academic research and scientific papers

Design and synthesis of 2-phenoxynicotinic acid hydrazides as anti-inflammatory and analgesic agents

A series of 2-phenoxynicotinic acid hydrazides were synthesized and evaluated for their analgesic and anti-inflammatory activities. Several compounds having an unsubstituted phenyl/4-pyridyl or C-4 methoxy substituent on the terminal phenyl ring showed moderate to high analgesic or antiinflammatory activity in comparison to mefenamic acid as the reference drug. The compounds with highest anti-inflammatory activity were subjected to in vitro COX-1/COX-2 inhibition assays and showed moderate to good COX-1 and weak COX-2 inhibition activities.

Substituted N'-(arylcarbonyl)-benzhydrazides, N'-(arylcarbonyl)-benzylidene-hydrazides and analogs as activators of caspases and inducers of apoptosis and the use thereof

The present invention is directed to substituted N′-(arylcarbonyl)-benzhydrazides, N′-(arylcarbonyl)-benzylidene-hydrazides and analogs thereof, represented by the Formulae I and II: wherein Ar1, Ar2, and R1-R2 are defined herein. The present invention also relates to the discovery that compounds having Formulae I and II are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.