475111-92-3

Upstream product

• 100-52-7 benzaldehyde 
• 10495-09-7 ethyl 4,4-diethoxyacetoacetate 

Downstream Products

• 115747-23-4 2-diethoxymethyl-6-methyl-4-phenyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester 
• 475111-93-4 2-formyl-6-methyl-4-phenyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester 

Relevant academic research and scientific papers

Synthesis of new C60 derivatives containing biologically active 4-aryl-1,4-dihydropyridines

Water-soluble pyrrolidino[3,4:1,2][60]fullerene derivatives bearing the biologically active 1,4-dihydropyridine (1,4-DHP) system have been synthesized through different chemical approaches depending upon the linkage position of the fulleropyrrolidine to the 1,4-DHP ring.

Chemistry of Hantzsch Cyclization: Stereochemistry of the 2-Hydroxy-1,2,3,4-tetrahydropyridine Intermediate of Hantzsch Cyclization. X-Ray Molecular Structure of Diastereoisomers of 5-(2-Cyanoethyl) 3-Methyl 2-Dimethoxymethyl-2-hydroxy-6-methyl-4-(3-nitrophenyl)-1,2,3,4-tetrahydropyri...

Hantzsch cyclization of cyanoethyl 3-aminocrotonate and (E,Z)-4,4-dialkoxy-2-benzylideneacetoacetonates 12a-h afforded the corresponding 3,4-trans-2-hydroxy-1,2,3,4-tetrahydropyridines 14a-h with high stereoselectivity. 1H NMR and X-ray analyses of compound 14a established the configuration of 3-H and 4-H as trans and that of 3-H and 2-OH as trans also.