475143-06-7

Upstream product

• 104701-87-3 3-tert-butyldimethylsilyloxy-2-methylpropanal 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 475051-45-7 (2R,3S,4S)-5-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-2,4-dimethyl-pentanoic acid ethyl ester 
• 125244-91-9 3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-2-methylpropan-1-ol 
• 625109-65-1 (2S,3R,4S)-5-(tert-Butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-2,4-dimethyl-pentan-1-ol 
• 475143-05-6 ethyl (2R,3S,4S)-5-(tert-butyldimethylsiloxy)-3-(4-methoxybenzyloxy)-2,4-dimethylpentanoate 
• 374896-36-3 ethyl (2R,3S,4S)-2-bromo-5-(tert-butyldimethylsiloxy)-3-hydroxy-2,4-dimethylpentanoate 
• 89238-99-3 O-(4-methoxybenzyl)-trichloroacetimidate 
• 153645-08-0 2-bromo-1-ethoxy-2-methyl-1-trimethylsilyoxyethene 
• 184292-01-1 (2R,3S,4S)-5-(tert-butyldimethylsiloxy)-3-(4-methoxybenzyloxy)-2,4-dimethylpentanal 

Downstream Products

• 475143-08-9 (2R,3S,4S,5S,6S)-7-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-5-(4-methoxy-benzyloxy)-2,4,6-trimethyl-heptanoic acid ethyl ester 

Relevant academic research and scientific papers

Regulated-stereoselective construction of thirteen stereogenic centers necessary for the frame of (+)-discodermolide, based on iterative Lewis acid-promoted aldol reactions

The segments C1-C13 and C15-C 21 containing the 13 stereogenic centers required for the frame of (+)-discodermolide were synthesized in good to excellent enantio- and diastereoselectivities from a common racemic

A short synthesis of the C15-C21 segment of (+)-discodermolide, based on an asymmetric approach from achiral 2-methyl-1,3-propanediol to versatile enantiopure stereotriads

A new approach was developed to versatile enantiopure stereotriads using chiral oxazaborolidinone-promoted asymmetric aldol reaction of a racemic aldehyde with a bromo silyl nucleophile. A short synthesis of the C15-C21 segment of (+