475272-52-7

Upstream product

• 90-11-9 1-Bromonaphthalene 
• 25016-01-7 5-bromo-2-methoxybenzaldehyde 
• 475272-37-8 (5-bromo-2-methoxy-phenyl)-naphthalene-1-yl-methanol 
• 475272-38-9 1-(5-bromo-2-methoxybenzyl)-naphthalene 
• 475272-39-0 2-(4-methoxy-3-naphthalene-1-ylmethyl-phenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane 
• 475272-04-9 2-(3-isobutyl-4-methoxyphenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane 
• 434300-54-6 4-(2-cyanoethyl)-2-isobutylphenyl trifluoromethanesulfonate 
• 475272-50-5 3-(2',2''-diisobutyl-4-methoxy-3-naphthalen-1-ylmethyl-[1,1':4',1'']-terphenyl-4''-yl)propionitrile 
• 475272-49-2 trifluoro-methanesulfonic acid 4'-(2-cyano-ethyl)-3,2'-diisobutyl-biphenyl-4-yl-ester 
• 475272-48-1 3-(4'-hydroxy2,3'-diisobutyl-biphenyl-4-yl)propionitrile 
• 863508-40-1 (E)-3-(3-Isobutyl-4-methoxy-phenyl)-acrylonitrile 
• 475272-06-1 3-(4-hydroxy-3-isobutylphenyl)propanenitrile 
• 475272-05-0 3-(3-isobutyl-4-methoxyphenyl)propanenitrile 
• 475272-03-8 4-iodo-2-isobutylanisole 

Downstream Products

• 475272-53-8 3-(2',2''-diisobutyl-4-methoxycarbonylmethoxy-3-naphthalen-1-ylmethyl-[1,1':4',1'']-terphenyl-4''-yl)propionic acid methyl ester 

Relevant academic research and scientific papers

Terphenyl-based helical mimetics that disrupt the p53/HDM2 interaction

(Chemical Equation Presented) HDM2 regulates p53 by binding to its transactivation domain and promoting its ubiquitin-dependent degradation. Crystallographic analysis of the HDM2/p53 complex revealed that three hydrophobic residues (F19, W23, L26) along one face of the p53 helical peptide are essential for binding (see picture). Terphenyl-based antagonists mimic the α-helical region of p53 and disrupt HDM2/p53 complexation.

Development of a potent Bcl-xL antagonist based on α-helix mimicry

The rational design of low-molecular weight ligands that disrupt protein-protein interactions is still a challenging goal in medicinal chemistry. Our approach to this problem involves the design of molecular scaffolds that mimic the surface functionality