47562-47-0Relevant academic research and scientific papers
Synthesis of retinals labelled with 13C in the cyclohexene ring
Gebhard, R.,Courtin, J. M. L.,Shadid, J. B.,Haveren, J. van,Haeringen, C. J. van,Lugtenburg, J.
, p. 207 - 214 (2007/10/02)
In this paper we report the synthesis of five retinals, specifically mono-labelled with 13C at the positions 1,2,3 and 4 and di-labelled with 13 C at the positions 16 and 17, with more than 98percent chemical purity and high 13C incorporation. (1-13C)- and (16,17-13C2) retinal were obtained in 20percent overall yield from (2-13C)- and (1,3-13C2)acetone, (2-13C)- and (3-13C)retinal were prepared in 10percent overall yield from (1-13C)- and (2-13C)acetonitrile, while (4-13C)retinal was synthesized in 17percent overall yield starting from (2-13C)acetonitrile.
