475649-32-2

Basic information

• Product Name: D-4'-TETRAHYDROPYRANYLGLYCINE
• Synonyms: 2H-Pyran-4-aceticacid,alpha-aminotetrahydro-,(alphaR)-(9CI);(R)-2-amino-2-(tetrahydro-2H-pyran-4-yl)acetic acid;REF DUPL: D-4'-Tetrahydropyranylglycine;2H-Pyran-4-acetic acid, .alpha.-aminotetrahydro-, (.alpha.R)-;(alphaR)-alpha-Aminotetrahydro-2H-pyran-4-acetic acid;2H-Pyran-4-acetic acid, α-aminotetrahydro-, (αR)-;(R)-a-Aminotetrahydro-2H-pyran-4-acetic acid;EOS-61298
• CAS NO: 475649-32-2
• Molecular Formula: C7H13NO3
• Molecular Weight: 159.19
• Product Categories: GLYCINESCAFFOLD
• Mol File: 475649-32-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 316.7°C at 760 mmHg
• Flash Point: 145.3°C
• Appearance: /
• Density: 1.211
• Vapor Pressure: 8.62E-05mmHg at 25°C
• Refractive Index: 1.505
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 2.25±0.10(Predicted)
• CAS DataBase Reference: D-4'-TETRAHYDROPYRANYLGLYCINE(CAS DataBase Reference)
• NIST Chemistry Reference: D-4'-TETRAHYDROPYRANYLGLYCINE(475649-32-2)
• EPA Substance Registry System: D-4'-TETRAHYDROPYRANYLGLYCINE(475649-32-2)

Safety Data

• Hazardous Substances Data: 475649-32-2(Hazardous Substances Data)

Usage

General Description

D-4'-Tetrahydropyranylglycine is a chemical compound that is commonly used in the pharmaceutical industry as a protection group for the carboxylic acid functional group in organic synthesis. It is derived from glycine and contains a tetrahydropyranylmethyl (THP) group attached to the nitrogen atom of the glycine molecule. This protective group is used to prevent unwanted interactions or reactions during the synthesis process, allowing for the selective manipulation of other functional groups within the molecule. D-4'-Tetrahydropyranylglycine is commonly used in the synthesis of various pharmaceuticals and bioactive compounds.

InChI:InChI=1/C7H13NO3/c8-6(7(9)10)5-1-3-11-4-2-5/h5-6H,1-4,8H2,(H,9,10)

Upstream product

• 50675-18-8 3,4,5,6-tetrahydro-2H-pyran-4-carbaldehyde 
• 151-50-8 potassium cyanide 
• 871261-02-8 2-oxo-2-(tetrahydro-2H-pyran-4-yl)acetic acid 
• 861160-58-9 C₉H₁₄O₄ 
• 5337-03-1 tetrahydro-2H-pyran-4-carboxylic acid 

Downstream Products

• 889949-63-7 2-amino-2-(tetrahydro-2H-pyran-4-yl)ethanol 

Relevant articles and documents

SYNTHESIS METHOD FOR L-CYCLIC ALKYL AMINO ACID AND PHARMACEUTICAL COMPOSITION HAVING THEREOF

A synthesis method for L-cyclic alkyl amino acid and a pharmaceutical composition having the said amino acid are provide in the present disclosure provides. The synthesis method comprises: step A.) preparing a cyclic alkyl keto acid or a cyclic alkyl keto acid salt having Structural Formula (I) or Structural Formula (II), and step B.) mixing the cyclic alkyl keto acid or the cyclic alkyl keto acid salt with ammonium formate, a leucine dehydrogenase, a formate dehydrogenase and a coenzyme NAD+, and carrying out a reductive amination reaction to generate the L-cyclic alkyl amino acid, wherein the Structural Formula (I) is where n1≧1, m1≧0 and the M1 is H or a monovalent cation; the Structural Formula (II) is where n2≧0, m2≧0, the M2 is H or a monovalent cation, an amino acid sequence of the leucine dehydrogenase is SEQ ID No.1.