889949-63-7

Basic information

• Product Name: 2-AMINO-2-(TETRAHYDRO-PYRAN-4-YL)-ETHANOL
• Synonyms: 2-AMINO-2-(TETRAHYDRO-2H-PYRAN-4-YL)ETHANOL;2-AMINO-2-(TETRAHYDRO-PYRAN-4-YL)-ETHANOL;2-AMINO-2-(OXAN-4-YL)ETHAN-1-OL
• CAS NO: 889949-63-7
• Molecular Formula: C₇H₁₅NO₂
• Molecular Weight: 145.2
• Product Categories: pharmacetical
• Mol File: 889949-63-7.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-AMINO-2-(TETRAHYDRO-PYRAN-4-YL)-ETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-2-(TETRAHYDRO-PYRAN-4-YL)-ETHANOL(889949-63-7)
• EPA Substance Registry System: 2-AMINO-2-(TETRAHYDRO-PYRAN-4-YL)-ETHANOL(889949-63-7)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 889949-63-7(Hazardous Substances Data)

Usage

General Description

2-AMINO-2-(TETRAHYDRO-PYRAN-4-YL)-ETHANOL is a chemical compound with the molecular formula C8H17NO2. It is a tertiary amine with a tetrahydropyran ring structure and an ethanol group. 2-AMINO-2-(TETRAHYDRO-PYRAN-4-YL)-ETHANOL has potential applications in pharmaceuticals and organic synthesis due to its unique structure and properties. It is used as a building block in the synthesis of various organic compounds and as a reagent in chemical reactions. Additionally, its functional groups make it a potential candidate for drug development and medicinal chemistry research.

Upstream product

• 477585-43-6 methyl 2-amino-2-(tetrahydro-2H-pyran-4-yl)acetate 
• 29943-42-8 Tetrahydro-4H-pyran-4-one 
• 477584-90-0 methyl 2-(((benzyloxy)carbonyl)amino)-2-(dihydro-2H-pyran-4(3H)-ylidene)acetate 
• 53284-84-7 2-amino-2-(oxan-4-yl)acetic acid 

Relevant articles and documents

Bcl-2 INHIBITORS

Disclosed herein is a compound of Formula (I) for inhibiting Bcl-2 and treating disease associated with undesirable bcl-2 activity (Bcl-2 related diseases), a method of using the compounds disclosed herein for treating dysregulated apoptotic diseases incl

HOT MELT EXTRUDED SOLID DISPERSIONS CONTAINING A BCL2 INHIBITOR

A pro-apoptotic solid dispersion comprises, a Bcl -2 family protein inhibitory compound of Formula A as defined herein, dispersed in a solid matrix that comprises (a) a pharmaceutically acceptable water-soluble polymeric carrier, and (b) a pharmaceutically acceptable surfactant. A process for preparing such a solid dispersion comprises subjecting to elevated temperature the compound of Formula A, the water-soluble polymeric carrier, and the surfactant to provide an extrudable semi-solid mixture; extruding the semi-solid mixture; and cooling the resulting extrudate to provide a solid matrix comprising the polymeric carrier, and the surfactant and having the compound dispersed in essentially non-crystalline form therein. The solid dispersion is suitable for oral administration to a subject in need thereof for treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl -2 family proteins, for example cancer or an immune or autoimmune disease.