475994-58-2

Basic information

• Product Name: 8-bromo-2-oxidoisoquinolin-2-ium
• Synonyms: 8-bromo-2-oxidoisoquinolin-2-ium
• CAS NO: 475994-58-2
• Molecular Weight: 224.057
• Mol File: 475994-58-2.mol

Chemical Properties

• CAS DataBase Reference: 8-bromo-2-oxidoisoquinolin-2-ium(CAS DataBase Reference)
• NIST Chemistry Reference: 8-bromo-2-oxidoisoquinolin-2-ium(475994-58-2)
• EPA Substance Registry System: 8-bromo-2-oxidoisoquinolin-2-ium(475994-58-2)

Safety Data

• Hazardous Substances Data: 475994-58-2(Hazardous Substances Data)

Upstream product

• 63927-22-0 8-bromo-isoquinoline 

Downstream Products

• 1233025-78-9 8-bromo-1-chloro-isoquinoline 
• 643069-25-4 8-bromo-1-methoxy-isoquinoline 
• 475994-60-6 8-bromo-2H-isoquinolin-1-one 

Relevant articles and documents

Rhodium-Catalyzed Atroposelective Construction of Indoles via C?H Bond Activation

Reported herein is the rhodium(III)-catalyzed C?H activation of anilines bearing an N-isoquinolyl directing group for oxidative [3+2] annulation with four classes of internal alkynes, leading to atroposelective indole synthesis via dynamic kinetic annulation with C-N reductive elimination constituting the stereo-determining step. This reaction proceeds under mild conditions with high regio- and enantioselectivity and functional group compatibility.

LIGHT-EMITTING MATERIAL HAVING POLYCYCLIC LIGAND

PROBLEM TO BE SOLVED: To provide a metal complex which can adjust light-emitting complexion of an element more efficiently while maintaining an extremely narrow half value full width when being used as a light-emitting material in the electroluminescent element, lowers a drive voltage of the element or maintains a low voltage level, improves efficiency of the element, and extremely greatly improves a useful life of the element. SOLUTION: A metal complex includes a ligand having a structure for instance, of a following chemical compound 9. An electroluminescent element includes the metal complex. SELECTED DRAWING: None COPYRIGHT: (C)2022,JPOandINPIT

TRICYCLIC DEGRADERS OF IKAROS AND AIOLOS

Tricyclic cereblon binders for the degradation of Ikaros or Aiolos by the ubiquitin proteasome pathway for therapeutic applications are described.

KRAS G12C INHIBITORS

The present invention relates to compounds that, inhibit KRas G12C, In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

Synthetic method for amine compounds of drug intermediate nitrogen heterocyclic ring

The invention relates to a synthetic method for amine compounds of a drug intermediate nitrogen heterocyclic ring. The synthetic method includes the steps that 8-bromoisoqunoline, acetic acid and hydrogen peroxide serve as raw materials, and are completely reacted at the temperature of 60 DEG C, a formaldehyde solution and a NaOH aqueous solution are added, extraction is carried out, and 8-bromoisoqunoline nitrogen oxide is obtained; in the presence of phosphorus oxychloride, the 8-bromoisoqunoline nitrogen oxide is added and poured into trash ice, the mixture is dissolved and washed with dichloromethane, and 8-bromine-1-chloroisoquinoline is obtained; in the presence of N,N-dimethylformamide, the 8-bromine-1-chloroisoquinoline and methoxybenzylamine are reacted till the reaction is completed, extraction is carried out with ethyl acetate, and 8-bromine-N-(4-metoxybenzene)-1-aminoisoquinolinone is obtained; the 8-bromine-N-(4-metoxybenzene)-1-aminoisoquinolinone is added into trifluoroacetic acid and backflows, trifluoroacetic acid is screwed off after the reaction is carried out, water is added, the PH is adjusted to be equal to 9, extraction and silica-gel column chromatographya are carried out, and a product is obtained.

HETEROAROMATIC NMDA RECEPTOR MODULATORS AND USES THEREOF

Disclosed herein, in part, are heteroaromatic compounds and methods of use in treating neuropsychiatric disorders, e.g., schizophrenia and major depressive disorder. Pharmaceutical compositions and methods of making heteroaromatic compounds are provided. The compounds are contemplated modulate the NMDA receptor.

SUBSTITUTED TRIAZOLOPYRIDINES AND ANALOGS THEREOF

The present invention relates to substituted triazolopyridines and analogs thereof, the use of the compounds as phosphodiesterase 10 (PDE10) inhibitors for the treatment of PDE10-modulated disorders, to pharmaceutical compositions comprising the compounds.

ANTIBACTERIAL COMPOUNDS

Cyclohexane and cyclohexene derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly man

Synthesis of novel substituted isoquinolones

A series of novel substituted isoquinolones have been synthesised. This has been achieved by two routes, either Curtius rearrangment of cinnamic acids or via an isoquinoline N-oxide.