476172-03-9

Upstream product

• 40138-16-7 2-formylbenzene boronic acid 
• 186792-13-2 4-bromo-5-methoxy-2-methylpyridazin-3(2H)-one 
• 933-76-6 4,5-dichloro-2-methyl-3(2H)-pyridazinone 
• 14628-57-0 4-chloro-5-methoxy-2-methyl-2H-pyridazin-3-one 

Downstream Products

• 854017-85-9 4-(2-bromomethyl-phenyl)-5-methoxy-2-methyl-2H-pyridazin-3-one 

Relevant academic research and scientific papers

Synthesis of new pyridazino[4,5-c]isoquinolinones by Suzuki cross-coupling reaction

Suzuki cross-coupling reaction of 2-alkyl(methyl and benzyl)-5-chloro-4-methoxy- and 2-alkyl(methyl and benzyl)-4-chloro-5-methoxypyridazin-3(2H)-ones with 2-formylphenylboronic acid afforded the corresponding biaryl products which were cyclized with ammonia to yield hitherto undescribed pyridazino[4,5-c]isoquinolinones. Removal of the N-benzyl protective group in position 2 yielded the unsubstituted tricyclic pyridazinones.