476445-29-1Relevant academic research and scientific papers
An efficient palladium-catalyzed coupling reaction of lithium alkynyltriisopropoxyborates with acid chlorides: A new access to synthesis of conjugated ynones
Oh, Chang Ho,Reddy, V. Raghava
, p. 8545 - 8548 (2007/10/03)
An efficient palladium-catalyzed protocol for the synthesis of ynones from lithium alkynyltriisopropoxyborates with acid chlorides under mild neutral conditions.
Highly stereoselective addition of stannylcuprates to alkynones
Nielsen, Thomas E.,Cubillo de Dios, Maria A.,Tanner, David
, p. 7309 - 7313 (2007/10/03)
The addition of stannylcuprate reagents such as (Bu3Sn)(PhS)CuLi to alkynones has been found to proceed in high yield and with excellent stereoselectivity for the Z isomer of the product (>95%). The behavior of the stannylcuprates is thus very different from that of their "carbocuprate" counterparts such as Me2CuLi or Me2Cu(CN)Li2 which are nonstereoselective. Furthermore, in contrast to the reactions of (R3Sn)(PhS)CuLi with the corresponding alkynoates, the presence of a proton source in the reaction medium has no effect on the stereoselectivity of the reaction of alkynones.
