476453-77-7Relevant academic research and scientific papers
Spectral and crystallographic study of pyridinic analogues of nimesulide: Determination of the active form of methanesulfonamides as COX-2 selective inhibitors
Julémont, Fabien,De Leval, Xavier,Michaux, Catherine,Damas, Jacques,Charlier, Caroline,Durant, Fran?ois,Pirotte, Bernard,Dogné, Jean-Michel
, p. 5182 - 5185 (2002)
Compound 7, N-(3-phenoxy-4-pyridinyl)trifluoromethanesulfonamide, showed in vitro (whole blood assay) a strong inhibitory activity on the two cyclooxygenase (COX) enzymes (IC50(COX1) = 2.2 μM and IC50(COX-2) = 0.4 μM), being more act
