28664-62-2

Basic information

• Product Name: 2-phenoxypyridin-3-amine
• Synonyms: 2-phenoxypyridin-3-amine;2-Phenoxy-3-pyridinaMine
• CAS NO: 28664-62-2
• Molecular Formula: C₁₁H₁₀N₂O
• Molecular Weight: 186.22
• Product Categories: Amines;Pyridines
• Mol File: 28664-62-2.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-phenoxypyridin-3-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenoxypyridin-3-amine(28664-62-2)
• EPA Substance Registry System: 2-phenoxypyridin-3-amine(28664-62-2)

Safety Data

• Hazardous Substances Data: 28664-62-2(Hazardous Substances Data)

Usage

General Description

2-phenoxypyridin-3-amine is a chemical compound that belongs to the class of pyridine derivatives and contains an amine functional group. It is a heterocyclic compound with a phenyl group attached to the nitrogen atom in the pyridine ring. 2-phenoxypyridin-3-amine has potential applications in pharmaceutical and agrochemical industries. It may be used as a building block in the synthesis of various biologically active molecules and as a precursor in the production of pesticides and herbicides. The chemical structure of 2-phenoxypyridin-3-amine makes it an important intermediate for the development of new drugs and agrochemical products.

Upstream product

• 5470-18-8 2-Chloro-3-nitropyridine 
• 108-95-2 phenol 
• 1480-87-1 2-fluoro-3-nitropyridine 
• 76893-44-2 3-nitropyridine-2-phenyl ether 

Downstream Products

• 476453-77-7 N-(2-phenoxy-3-pyridinyl)methanesulfonimide 
• 1400637-82-2 C₂₁H₁₉BrN₂O₃ 
• 1400637-67-3 C₂₁H₁₉⁽¹⁸⁾FN₂O₃ 
• 1245623-84-0 N-[2-(2-fluoroethoxy)benzyl]-N-(2-phenoxy pyridin-3-yl)acetamide 
• 1207345-63-8 N-[2-(2-fluoroethoxy)-5-methoxybenzyl]-N-(2-phenoxypyridin-3-yl)acetamide 
• 1400637-54-8 C₂₁H₁₉FN₂O₃ 
• 1423008-63-2 C₁₈H₁₃F₂N₃O₂ 
• 1245623-79-3 C₂₂H₂₁⁽¹⁸⁾FN₂O₃ 

Relevant articles and documents

Chemical validation of a druggable site on Hsp27/HSPB1 using in silico solvent mapping and biophysical methods

Destabilizing mutations in small heat shock proteins (sHsps) are linked to multiple diseases; however, sHsps are conformationally dynamic, lack enzymatic function and have no endogenous chemical ligands. These factors render sHsps as classically “undruggable” targets and make it particularly challenging to identify molecules that might bind and stabilize them. To explore potential solutions, we designed a multi-pronged screening workflow involving a combination of computational and biophysical ligand-discovery platforms. Using the core domain of the sHsp family member Hsp27/HSPB1 (Hsp27c) as a target, we applied mixed solvent molecular dynamics (MixMD) to predict three possible binding sites, which we confirmed using NMR-based solvent mapping. Using this knowledge, we then used NMR spectroscopy to carry out a fragment-based drug discovery (FBDD) screen, ultimately identifying two fragments that bind to one of these sites. A medicinal chemistry effort improved the affinity of one fragment by ~50-fold (16 μM), while maintaining good ligand efficiency (~0.32 kcal/mol/non-hydrogen atom). Finally, we found that binding to this site partially restored the stability of disease-associated Hsp27 variants, in a redox-dependent manner. Together, these experiments suggest a new and unexpected binding site on Hsp27, which might be exploited to build chemical probes.

Synthesis of pyrido[2,3-b][1,4]benzoxazepines via a Friedel-Crafts cyclization

(Formula Presented.) An efficient and practical method has been developed for the synthesis of 6-aryl-substituted pyrido[2,3-b][1,4]benzoxazepines via a Friedel-Crafts reaction of readily accessible 2-phenoxypyridin-3-amines and aromatic acids.

Discovery of 2-(phenoxypyridine)-3-phenylureas as small molecule P2Y 1 antagonists

Two distinct G protein-coupled purinergic receptors, P2Y1 and P2Y12, mediate ADP-driven platelet activation. The clinical effectiveness of P2Y12 blockade is well established. Recent preclinical data suggest that P2Y1