622-04-8

Basic information

• Product Name: 1,3-Diphenoxy-2-propanol
• Synonyms: 1,3-DIPHENOXY-2-PROPANOL;1,3-difenoxy-2-propanol;1,3-diphenoxy-2-propano;1,3-diphenoxypropan-2-ol;1,3-Diphenoxy-2-propanol, 98+%;Glycerol 1,3-diphenyl ether;1,3-Bisphenoxy-2-propanol;Glycerol α,γ-diphenyl ether
• CAS NO: 622-04-8
• Molecular Formula: C₁₅H₁₆O₃
• Molecular Weight: 244.29
• EINECS: 210-718-8
• Mol File: 622-04-8.mol
• Article Data: 34

Chemical Properties

• Melting Point: 80-82°C
• Boiling Point: 347.2°C (rough estimate)
• Flash Point: 193.8 °C
• Appearance: /
• Density: 1.1790
• Vapor Pressure: 5.21E-07mmHg at 25°C
• Refractive Index: 1.5570 (estimate)
• PKA: 13.55±0.20(Predicted)
• CAS DataBase Reference: 1,3-Diphenoxy-2-propanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Diphenoxy-2-propanol(622-04-8)
• EPA Substance Registry System: 1,3-Diphenoxy-2-propanol(622-04-8)

Safety Data

• Statements: 22-36/37/38
• Safety Statements: 26-36/37
• RTECS: UB4100000
• Hazardous Substances Data: 622-04-8(Hazardous Substances Data)

Usage

General Description

1,3-Diphenoxy-2-propanol is a chemical compound that is typically presented in the form of a clear liquid. Its molecular formula is C15H16O3 and it is characterized by the presence of a three-carbon backbone with two aromatic phenol groups and one hydroxyl group attached. This chemical compound is highly stable, and it is neither highly reactive nor explosive. As with many organic compounds, precautions should be taken to avoid exposure or ingestion as it may be harmful or have toxic effects. Its applications range from being used as an intermediate in organic synthesis to being a component in certain types of polymers or resins.

InChI:InChI=1/C15H16O3/c16-13(11-17-14-7-3-1-4-8-14)12-18-15-9-5-2-6-10-15/h1-10,13,16H,11-12H2

Upstream product

• 4540-44-7 1-bromo-3-chloro-propan-2-ol 
• 100-67-4 potassium phenolate 
• 96-23-1 1,3-Dichloro-2-propanol 
• 139-02-6 sodium phenoxide 
• 102-76-1 triacetylglycerol 
• 4769-73-7 (RS)-1-chloro-3-phenyloxy-2-propanol 
• 141-52-6 sodium ethanolate 
• 108-95-2 phenol 
• 26272-86-6 fluoro-3 oxetane 
• 93-99-2 benzoic acid phenyl ester 
• 122-60-1 Phenyl glycidyl ether 
• 65-85-0 benzoic acid 
• 64-17-5 ethanol 
• 7732-18-5 water 

Downstream Products

• 94265-61-9 2-Ethoxymethoxy-1,3-diphenoxy-propan 
• 119117-50-9 1,3-bis(benzyloxy)propan-2-yl methanesulfonate 
• 95486-30-9 2-<2-Methoxycarbonyl-ethoxy>-1,3-diphenoxy-propan 
• 92553-36-1 2-chloro-1,3-diphenoxy-propane 
• 57641-54-0 1,3-bis-(4-bromo-phenoxy)-propan-2-ol 
• 94762-58-0 2-Butyloxymethoxy-1,3-diphenoxy-propan 
• 95427-42-2 2-<2-Cyan-ethoxy>-1,3-diphenoxy-propan 
• 96767-12-3 2-Propyloxymethoxy-1,3-diphenoxy-propan 
• 94963-07-2 2-Pentyloxymethoxy-1,3-diphenoxy-propan 
• 71159-31-4 2-Acetoxy-1,3-diphenoxy-propan 
• 67834-53-1 1,3-diphenyl-2-benzoylglycerol 

Relevant articles and documents

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Full atom-efficiency transformation of wasted polycarbonates into epoxy thermosets and the catalyst-free degradation of the thermosets for environmental sustainability

We report two sustainable features in this work. The first feature is that we successfully applied wasted polycarbonate (WPC) as an epoxy curing agent for epoxy resins to prepare WPC-cured epoxy thermosets. The curing of WPC and epoxy is based on the reaction of a carbonate and an epoxide, which is proven by a model reaction of diphenyl carbonate (DPC) and glycidyl phenyl ether (GPE) in the presence of a catalytic amount of 4-dimethylaminopyridine (DMAP). The WPC-cured epoxy thermosets show comparable thermal properties to commercial-based, phenol novolac (PN)-cured epoxy thermosets. Interestingly, the films of WPC-cured epoxy thermosets are foldable, while those of PN-cured epoxy thermosets are brittle, demonstrating the advantage of using WPC as a curing agent over PN. Since the WPC was used directly without any digestion or pyrolysis process, the atomic efficiency is 100percent, making this WPC recycling strategy economically attractive. The second feature is that we successfully degraded the WPC-cured epoxy thermosets to phenoxy resins through a catalyst-free aminolysis process, that is, the products based on the WPC-cured epoxy thermosets are degradable when their lifespans are expired. The transformation of WPC into epoxy thermosets, along with the degradation of the epoxy thermosets, makes this work attractive for sustainability.

Synthesis and antileishmanial activity of 1,3-bis(aryloxy)propan-2-amines

We describe herein the antileishmanial activity of 1,3-bis(aryloxy)propan-2-amines, prepared in four simple steps from epichlorohydrin. Among the evaluated compounds, three (4o, 4q, and 4r) displayed considerable activity against Leishmania amazonensis promastigote forms, with IC50 values below 10 μM. We also analyzed the effects of the nature and the position of ring substituent on activity. Two amines (4m and 4o) showed excellent profiles in the treatment of L. amazonensis-infected macrophages, reducing the parasite burden by more than 95% in tested concentrations.

New bent-shaped azomethine monomers for optical applications

It was convenient preparative method of new methacrylic monomers with banana-shaped structure and photoactive azomethine fragments synthesis. To determine the effect of large azomethine fragment on the process of homopolymerization, symmetrical model compounds with simpler structure were synthesized. The kinetic of its thermally initiated radical polymerization in DMF solution was studied and compared with the kinetics of model compounds does not containing bulky photochromic fragment. Peculiarities of photo initiated processes of E,Z-isomerization were studied.