4769-95-3

Usage

Uses

Used in Pharmaceutical Research:
1-(4-NITRO-1H-INDOL-3-YL)-ETHANONE is used as a key intermediate in the synthesis of various pharmaceutical compounds for [application reason]. Its unique chemical structure allows for the development of new drugs with potential therapeutic benefits.
Used in Organic Synthesis:
1-(4-NITRO-1H-INDOL-3-YL)-ETHANONE is used as a building block in the synthesis of various organic compounds in the chemical industry. Its versatile chemical properties enable the creation of a wide range of molecules with different applications.
Used in Drug Development:
1-(4-NITRO-1H-INDOL-3-YL)-ETHANONE is used as a starting material in the development of new drugs, particularly in the field of medicinal chemistry. Its potential applications in drug discovery make it a valuable asset in the search for novel therapeutic agents.

Upstream product

• 4769-97-5 4-nitro-1H-indoIe 
• 75-36-5 acetyl chloride 
• 108-24-7 acetic anhydride 
• 703-80-0 3-acetylindole 

Downstream Products

• 72527-77-6 3-acetyl-4-iodoindole 
• 4769-97-5 4-nitro-1H-indoIe 
• 1311395-37-5 3-acetyl-N-[4-(methylphenyl)sulfonyl]-4-nitro-1H-indole 

Relevant academic research and scientific papers

Ketone-Directed Cobalt(III)-Catalyzed Regioselective C2 Amidation of Indoles

An efficient cobalt(III)-catalyzed method for the direct C-H amidation of unprotected indoles for 2-amino indole scaffold construction has been developed. With dioxazolone as the amidating reagent, a variety of 2-amino indole derivatives were achieved in moderate to excellent yields using an organic acid as the additive and a ketone as the directing group.

Synthesis, protein kinase inhibitory potencies, and in vitro antiproliferative activities of meridianin derivatives

The synthesis of new meridianin derivatives is described. The indolic ring system was substituted at the C-4 to C-7 positions either by a bromine atom or by nitro or amino groups. Additionally, an iodine atom or various aryl groups were introduced at the C-5 position of the 2-aminopyrimidine ring. These compounds as well as some of their synthetic intermediates were tested for their kinase inhibitory potencies and for their in vitro antiproliferative activities. We found that this series of compounds is particularly interesting in the development of new inhibitors of DYRK1A and CLK1 kinases. The most effective compounds toward these two kinase families are the 6- and 7-bromo derivatives 30, 33, and 34 that showed more than 45-fold selectivity toward DYRK1A/CLK1 kinases over the other kinases tested. Meridianin derivatives could thus be developed toward potent and selective inhibitors of key RNA splicing regulators and potential therapeutic agents.

Friedel-Crafts acylation of indoles in acidic imidazolium chloroaluminate ionic liquid at room temperature

A practical and convenient protocol has been developed for the acidic 1-ethyl-3-methylimidazolium chloroaluminate ionic liquid (generated from 1-ethyl-3-methylimidazolium chloride (EmimCl) and aluminium chloride (X(AlCl3), mole fraction X=0.67-0.75) promoted Friedel-Crafts acylation of indoles at room temperature. The simple experimental procedure provides 3-substituted indoles in good to high yields with less electron rich indole ring systems.