4769-95-3

Basic information

• Product Name: 1-(4-NITRO-1H-INDOL-3-YL)-ETHANONE
• Synonyms: 1-(4-NITRO-1H-INDOL-3-YL)-ETHANONE;3-ACETYL-4-NITROINDOLE
• CAS NO: 4769-95-3
• Molecular Formula: C₁₀H₈N₂O₃
• Molecular Weight: 204.18
• Mol File: 4769-95-3.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-(4-NITRO-1H-INDOL-3-YL)-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-NITRO-1H-INDOL-3-YL)-ETHANONE(4769-95-3)
• EPA Substance Registry System: 1-(4-NITRO-1H-INDOL-3-YL)-ETHANONE(4769-95-3)

Safety Data

• Hazardous Substances Data: 4769-95-3(Hazardous Substances Data)

Usage

General Description

1-(4-NITRO-1H-INDOL-3-YL)-ETHANONE, also known as 4-Nitro-3-indoleethyl ketone, is a chemical compound with the molecular formula C10H8N2O3. It is a yellow crystalline substance that is commonly used in organic synthesis and pharmaceutical research. 1-(4-NITRO-1H-INDOL-3-YL)-ETHANONE is a derivative of indole, which is a heterocyclic aromatic organic compound. 1-(4-NITRO-1H-INDOL-3-YL)-ETHANONE has potential applications in the development of new drugs and as a building block in the synthesis of various organic compounds. It is important to handle this chemical with care, as it may pose health hazards and environmental risks if not properly managed.

Upstream product

• 4769-97-5 4-nitro-1H-indoIe 
• 108-24-7 acetic anhydride 
• 75-36-5 acetyl chloride 
• 703-80-0 3-acetylindole 

Downstream Products

• 4769-97-5 4-nitro-1H-indoIe 
• 1311395-37-5 3-acetyl-N-[4-(methylphenyl)sulfonyl]-4-nitro-1H-indole 
• 72527-77-6 3-acetyl-4-iodoindole 

Relevant articles and documents

Ketone-Directed Cobalt(III)-Catalyzed Regioselective C2 Amidation of Indoles

An efficient cobalt(III)-catalyzed method for the direct C-H amidation of unprotected indoles for 2-amino indole scaffold construction has been developed. With dioxazolone as the amidating reagent, a variety of 2-amino indole derivatives were achieved in moderate to excellent yields using an organic acid as the additive and a ketone as the directing group.

Friedel-Crafts acylation of indoles in acidic imidazolium chloroaluminate ionic liquid at room temperature

A practical and convenient protocol has been developed for the acidic 1-ethyl-3-methylimidazolium chloroaluminate ionic liquid (generated from 1-ethyl-3-methylimidazolium chloride (EmimCl) and aluminium chloride (X(AlCl3), mole fraction X=0.67-0.75) promoted Friedel-Crafts acylation of indoles at room temperature. The simple experimental procedure provides 3-substituted indoles in good to high yields with less electron rich indole ring systems.